C. Cloix

Mitochondrial outer membrane integrity regulates a ubiquitin-dependent NF-κB inflammatory response

This study shows that mitochondrial outer membrane permeabilization triggers ubiquitin-dependent NF-κB inflammation by recruiting NEMO to ubiquitylated mitochondria.

Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage

This study shows mitochondrial dysfunction promotes DNA damage through caspase-dependent mechanisms regulated by mitochondrial dynamics.

Increased apoptotic priming of glioblastoma enables therapeutic targeting by BH3-mimetics

This study shows that glioblastoma (GBM) is highly sensitive to BH3-mimetics due to elevated anti-apoptotic BCL-xL and MCL-1 expression, which can be therapeutically targeted.

Quantitative in vivo bioluminescence imaging of orthotopic patient-derived glioblastoma xenografts

This paper demonstrates the use of iRFP expression in patient-derived glioblastoma cells for non-invasive, quantitative monitoring of tumor growth in vivo.