Author

K. Klepac

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:metabolism & bioenergetics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

J. Szendroedi· 2 shared S. Herzig· 2 shared A. Bartelt· 1 shared A. Feuchtinger· 1 shared A. Georgiadi· 1 shared A. J. Alfaro Nunez· 1 shared A. Loft· 1 shared A. Maida· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersPhysiology

J. Szendroedi

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3 papers

Recent·Most cited

Differential cell type-specific function of the aryl hydrocarbon receptor and its repressor in diet-induced obesity and fibrosis

F. J. Graelmann, F. Gondorf, Y. Majlesain, B. Niemann, K. Klepac, M. Gottschalk, M. Mayer, I. Iriady, P. Hatzfeld, S. K. Lindenberg, K. Wunderling, C. Thiele, Z. Abdullah, W. He, K. Hiller, , L. Reverte-Salisa

This study investigates the cell type-specific roles of AhR and AhRR in diet-induced obesity and fibrosis, finding that AhRR deficiency protects from metabolic dysfunction and liver damage, while AhR deficiency worsens outcomes.

Molecular Metabolism · Jul 1, 2024Peer-reviewedImmunology

Chronic intermittent fasting impairs β-cell maturation and function in adolescent mice

L. Matta, P. Weber, S. Erener, A. Walth-Hummel, D. Hass, L. K. Buehler, K. Klepac, J. Szendroedi, J. Guerra, M. Rohm, M. Sterr, H. Lickert, A. Bartelt, S. Herzig

This study shows chronic intermittent fasting impairs β-cell maturation and function in adolescent mice, but not in adults, with similar patterns observed in human type 1 diabetes.

bioRxiv · Apr 18, 2024Physiology

Fasting-sensitive SUMO-switch on Prox1 controls hepatic cholesterol metabolism

A. J. Alfaro Nunez, C. Dittner, J. Becker, A. Loft, A. Mhamane, A. Maida, A. Georgiadi, P. Tsokanos, K. Klepac, E. Molocea, R. Merahbi, K. Motzler, J. Geppert, R. Karikari, J. Szendroedi, , S. Herzig

This study shows that SUMOylation of Prox1 regulates hepatic cholesterol metabolism in response to fasting, with implications for metabolic health.

bioRxiv · Aug 17, 2022Physiology