M. Gottschalk

Differential cell type-specific function of the aryl hydrocarbon receptor and its repressor in diet-induced obesity and fibrosis

This study investigates the cell type-specific roles of AhR and AhRR in diet-induced obesity and fibrosis, finding that AhRR deficiency protects from metabolic dysfunction and liver damage, while AhR deficiency worsens outcomes.

The emergence and diversification of a zoonotic pathogen from within the microbiota of intensively farmed pigs

This study traces the emergence and spread of Streptococcus suis pathogens in pigs, linking their evolution to changes in farming practices and identifying genomic factors associated with pathogenicity.

Mutation rate dynamics reflect ecological change in an emerging zoonotic pathogen

The paper investigates how mutation rates in Streptococcus suis change with ecology and genome size, finding higher mutation rates in invasive disease isolates and a bias towards G/C to A/T mutations in more pathogenic strains.

Capsular polysaccharide switching in Streptococcus suis modulates host cell interactions and virulence

This study shows that serotype switching in Streptococcus suis can differentially affect host cell interactions and virulence, with some serotypes increasing or decreasing pathogenicity.

Genome reduction is associated with bacterial pathogenicity across different scales of temporal and ecological divergence

The paper investigates whether genome reduction is linked to bacterial pathogenicity across different scales of divergence and finds it consistently associated with reduced genome size in pathogens.

A comprehensive portrait of antimicrobial resistance in the zoonotic pathogen Streptococcus suis

This study examines antimicrobial resistance in Streptococcus suis using MIC measurements and whole-genome sequencing, identifying resistance determinants and highlighting the complexity of resistance mechanisms.