K. L. Nastiuk

Androgen deprivation triggers a cytokine signaling switch to induce immune suppression and prostate cancer recurrence

Stromal resistance to castration-induced prostate regression in a mouse model of benign prostatic hyperplasia

This study shows that stromal compartments in a mouse model of BPH are resistant to castration-induced regression, suggesting the need for additional therapies.

TNF signaling is required for castration-induced vascular damage preceding prostate cancer regression

This study shows TNF signaling is required for castration-induced vascular damage in prostate cancer, which contributes to tumor regression.

Glucocorticoid signaling delays castration-induced regression in murine models of prostate cancer

This study shows that glucocorticoid signaling delays castration-induced regression in murine prostate cancer models by maintaining tumor proliferation through GR activation, which can be blocked by the GR antagonist relacorilant.

TNF Blockade Reduces Prostatic Hyperplasia and Inflammation while Limiting BPH Diagnosis in Patients with Autoimmune Disease

Patient data and mouse models suggest that repurposing tumor necrosis factor alpha blockade reduces inflammation-mediated prostatic hyperplasia.