K. Lebrigand

Cell culture differentiation and proliferation conditions influence the in vitro regeneration of the human airway epithelium

This study evaluates how different culture media affect the differentiation and proliferation of human airway epithelial cells in vitro using single-cell RNA sequencing and imaging.

Aging affects reprogramming of murine pulmonary capillary endothelial cells after lung injury

This study compares transcriptomic changes in pulmonary capillary endothelial cells from young and aged mice after lung injury, finding age-related differences in resolution and fibrotic signatures.

Identification of oncolytic vaccinia restriction factors in canine high-grade mammary tumor cells using single-cell transcriptomics

This paper uses single-cell transcriptomics to identify DDIT4 as a resistance factor against oncolytic vaccinia virus in canine TNBC cells.

High dimensional single-cell analysis reveals iNKT cell developmental trajectories and effector fate decision

The paper uses single-cell transcriptomics to uncover developmental trajectories of iNKT cells and identifies FHL2 as a regulator of iNKT1 fate.

Single-cell RNA sequencing reveals novel cell differentiation dynamics during human airway epithelium regeneration

This study uses single-cell RNA sequencing to uncover differentiation dynamics and cell trajectories in human airway epithelium regeneration, identifying novel cell subpopulations and signaling pathways involved.

Targeting the DNM3OS / miR-199a~214 cluster for the treatment of fibroproliferative diseases

This study identifies DNM3OS as a key regulator of fibroblast activation via miRNAs, offering a therapeutic target for fibrotic diseases like IPF.