K. Lindblad-Toh

Interpreting mammalian evolutionary constraint at synonymous sites in light of the unwanted transcript hypothesis

The paper examines mammalian evolutionary constraint at synonymous sites, finding significant constraint in 20.8% of four-fold degenerate sites and biases toward G/C content and splice sites.

Using evolutionary constraint to define novel candidate driver genes in medulloblastoma

The paper identifies novel candidate driver genes in medulloblastoma by analyzing non-coding constraint mutations across pediatric brain tumors and comparing them to benign tumors.

Three-dimensional genome re-wiring in loci with Human Accelerated Regions

The paper identifies human-specific 3D genome re-wiring in conserved loci, linking accelerated evolution to regulatory rewiring in neural progenitor cells.

Canine oral melanoma genomic and transcriptomic study defines two molecular subgroups with different therapeutical targets

This study identifies two molecular subgroups of canine oral melanoma with distinct therapeutic targets, suggesting potential for tailored treatments in humans.

Hemangiosarcoma Cells Promote Conserved Host-Derived Hematopoietic Expansion

This study shows that hemangiosarcoma cells create a microenvironment that supports hematopoietic expansion, resembling bone marrow niche cells.

Genomically Complex Human Angiosarcoma and Canine Hemangiosarcoma Establish Convergent Angiogenic Transcriptional Programs Driven by Novel Gene Fusions

This study identifies novel fusion genes in human angiosarcomas and canine hemangiosarcomas, showing convergent transcriptional programs driven by these fusions and mutations in TP53 and PI3K/AKT/mTOR pathway genes.

How to make a rodent giant: Genomic basis and tradeoffs of gigantism in the capybara, the world’s largest rodent

This study sequenced the capybara genome to investigate the genetic basis of gigantism and related tradeoffs, finding elevated mutation load and novel anticancer mechanisms.