Author

K. M. Clark

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2

Frequent Co-Authors

L. Shan· 2 shared Q. Wang· 2 shared C. J. DeSelm· 1 shared G. H. Harlan· 1 shared H. Gao· 1 shared P. Tang· 1 shared R. M. Presti· 1 shared S. B. Kutluay· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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2 shared papersMicrobiology

L. Shan

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2 papers

Recent·Most cited

CARD8 inflammasome sensitization through DPP9 inhibition enhances NNRTI-triggered killing of HIV-1-infected cells

K. M. Clark, Q. Wang, L. Shan

The paper shows that inhibiting DPP9 with Val-boroPro enhances NNRTI-induced killing of HIV-1-infected cells by sensitizing the CARD8 inflammasome.

bioRxiv · Sep 1, 2021 · PreprintMicrobiology

CARD8 inflammasome mediates pyroptosis of HIV-1-infected cells by sensing viral protease activity

Q. Wang, H. Gao, K. M. Clark, P. Tang, G. H. Harlan, S. B. Kutluay, C. J. DeSelm, R. M. Presti, L. Shan

This study identifies CARD8 as a sensor of HIV-1 protease activity, triggering pyroptosis of infected cells and clearing latent HIV-1 in CD4+ T cells.

bioRxiv · Sep 25, 2020 · PreprintImmunology