Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
8 papers
Recent·Most cited
M. Puray-Chavez, J. E. Eschbach, M. Xia, K. LaPak, Q. Zhou, R. Jasuja, J. Pan, J. Xu, Z. Zhou, S. Mohammed, Q. Wang, D. Lawson, S. Djokic, G. Hou, S. Ding, , S. B. Kutluay
This study identifies tonic activation of the cGAS-STING and IFN pathways in ACE2-positive airway cells as a factor limiting SARS-CoV-2 replication.
bioRxiv · Jan 7, 2024Microbiology
Q. Zeng, A. Antia, M. P. Chavez, S. B. Kutluay, S. Ding
This study identifies calpain-2 as a host factor facilitating SARS-CoV-2 entry and shows calpain inhibitors inhibit viral infection through an Mpro-independent pathway.
bioRxiv · Nov 29, 2022 · PreprintMicrobiology
M. Puray-Chavez, K. M. Lapak, T. P. Schrank, J. L. Elliott, D. P. Bhatt, M. J. Agajanian, R. Jasuja, D. Q. Lawson, K. Davis, P. W. Rothlauf, H. Jo, N. Lee, K. Tenneti, J. E. Eschbach, C. Shema Mugisha, , S. B. Kutluay
This study identifies H522 cells as ACE2-negative human cells permissive to SARS-CoV-2 infection, revealing alternative receptor usage and host response mechanisms.
bioRxiv · Mar 1, 2021Microbiology
M. Zafferani, C. Haddad, L. Luo, J. Davila-Calderon, L. Yuan-Chiu, C. Shema Mugisha, A. G. Monaghan, A. A. Kennedy, J. D. Yesselman, R. R. Gifford, A. W. Tai, S. B. Kutluay, M.-L. Li, G. Brewer, B. S. Tolbert, A. E. Hargrove
This study identifies amilorides as small molecules that inhibit SARS-CoV-2 replication by targeting conserved RNA structures in the 5-UTR region.
bioRxiv · Dec 5, 2020Microbiology
M. Puray-Chavez, K. Tenneti, N. Lee, Y. Wang, H. R. Vuong, Y. Liu, A. Horani, T. Huang, S. P. Gunsten, J. B. Case, W. Yang, M. S. Diamond, S. L. Brody, J. Dougherty, S. B. Kutluay
This study uses ribosome profiling to analyze SARS-CoV-2 and host mRNA translation in infected cells, finding that viral mRNAs are not more efficiently translated than host mRNAs and highlighting unique translational strategies.
bioRxiv · Nov 3, 2020 · PreprintMicrobiology
Q. Wang, H. Gao, K. M. Clark, P. Tang, G. H. Harlan, S. B. Kutluay, C. J. DeSelm, R. M. Presti, L. Shan
This study identifies CARD8 as a sensor of HIV-1 protease activity, triggering pyroptosis of infected cells and clearing latent HIV-1 in CD4+ T cells.
bioRxiv · Sep 25, 2020 · PreprintImmunology
C. Shema Mugisha, H. R. Vuong, M. Puray-Chavez, S. B. Kutluay
This paper develops a Q-RT-PCR assay to monitor SARS-CoV-2 growth in cell culture without RNA extraction, showing it can identify inhibitors of viral replication.
bioRxiv · Jun 26, 2020 · PreprintMicrobiology
J. Elliott, J. E. Eschbach, P. C. Koneru, W. Li, M. Puray Chavez, D. Townsend, D. Lawson, A. N. Engelman, M. Kvaratskhelia, S. B. Kutluay
This study identifies three mechanisms by which class II HIV-1 integrase substitutions disrupt IN-RNA interactions, leading to virion maturation defects and premature viral genome degradation.
bioRxiv · Dec 18, 2019Microbiology