Free fatty acid receptor 4 is a nutrient sensor that resolves inflammation to maintain cardiac homeostasis
K. A. Murphy, B. A. Harsch, C. L. Healy, S. S. Joshi, S. Huang, R. E. Walker, B. M. Wagner, K. M. Ernste, W. Huang, R. Block, C. D. Wright, N. Tintle, B. C. Jensen, G. C. Shearer, T. D. O'Connell
This study shows Ffar4 resolves inflammation in the heart by sensing fatty acids and promoting anti-inflammatory oxylipin production, preventing cardiac remodeling.
bioRxiv · Sep 25, 2019 · PreprintPhysiology