Author

G. C. Shearer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

B. M. Wagner· 2 shared C. L. Healy· 2 shared K. A. Murphy· 2 shared B. A. Harsch· 1 shared B. C. Jensen· 1 shared B. Harsch· 1 shared C. D. Wright· 1 shared D. A. Orchard· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersPhysiology

B. M. Wagner

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2 papers

Recent·Most cited

Free fatty acid receptor 4 (FFAR4) regulates cardiac oxylipin balance to promote inflammation resolution in a model of heart failure preserved ejection fraction secondary to metabolic syndrome

N. Zhang, K. A. Murphy, B. Harsch, M. Zhang, D. J. Gyberg, B. M. Wagner, J. Mendelson, M. T. Patterson, D. A. Orchard, C. L. Healy, J. W. Williams, G. C. Shearer, T. O'Connell

This study shows that Ffar4 loss worsens cardiac inflammation and remodeling in male HFpEF-MetS mice by altering oxylipin balance.

bioRxiv · Apr 13, 2022 · PreprintPhysiology

Free fatty acid receptor 4 is a nutrient sensor that resolves inflammation to maintain cardiac homeostasis

K. A. Murphy, B. A. Harsch, C. L. Healy, S. S. Joshi, S. Huang, R. E. Walker, B. M. Wagner, K. M. Ernste, W. Huang, R. Block, C. D. Wright, N. Tintle, B. C. Jensen, G. C. Shearer, T. D. O'Connell

This study shows Ffar4 resolves inflammation in the heart by sensing fatty acids and promoting anti-inflammatory oxylipin production, preventing cardiac remodeling.

bioRxiv · Sep 25, 2019 · PreprintPhysiology