Cell BiologybioRxiv
Size-dependent protein segregation creates a spatial switch for Notch signaling and function
M. Kwak, K. M. Southard, N. H. Kim…·Y.-w. Jun
The paper shows that spatial constraints at cadherin-based adherens junctions regulate Notch cleavage by gamma-secretase, affecting signaling and cell differentiation.
DOI 10.1038/s41556-022-01031-6