N. H. Kim

Bimodality in Ras signaling originates from processivity of the Ras activator SOS without classic kinetic bistability

The paper shows that Ras signaling bimodality arises from SOS processivity, not kinetic bistability, and is controlled by scaffold protein condensation.

Plasma membrane association and resistosome formation of plant helper immune receptors

This study identifies the role of positively charged residues in helper NLRs for phospholipid binding and plasma membrane association, and shows effector activation induces NRG1 oligomerization at the plasma membrane.

The metabolite alpha-ketobutyrate increases health and life spans by activating AMPK

This paper shows that alpha-ketobutyrate extends lifespan and healthspan in C. elegans and mice by activating AMPK through MACF1/VAB-10.

Allelic variation in the Arabidopsis TNL CHS3/CSA1 immune receptor pair reveals two functional regulatory modes

The paper identifies two regulatory modes in the Arabidopsis CHS3/CSA1 immune receptor pair, showing how an integrated domain (ID) in clade 1 CHS3 enables effector binding, while other clades rely on detecting effector-modified pattern recognition receptors.

Emergence of glycogen synthase kinase-3 interaction domain enhances phosphorylation of SARS-CoV-2 nucleocapsid protein

This study identifies a GSK-3 interacting domain in SARS-CoV-2 N protein that enhances its phosphorylation, with mutations in variants like Delta and Omicron increasing N abundance and phosphorylation.

The plant immune receptors NRG1.1 and ADR1 are calcium influx channels

The paper identifies NRG1.1 and ADR1 as plant immune receptors that function as calcium-permeable channels to induce cell death.

Size-dependent protein segregation creates a spatial switch for Notch signaling and function

The paper shows that spatial constraints at cadherin-based adherens junctions regulate Notch cleavage by gamma-secretase, affecting signaling and cell differentiation.