Disease Modifying Osteoarthritis Drug Discovery Using A Temporal Phenotypic Reporter In Primary Human Chondrocytes
M. A. Cruz, S. Gronowicz, M. Karimzadeh, K. Martyniak, R. Medam, T. J. Kean
The paper identifies aromoline as a novel drug candidate that increases type II collagen in primary human chondrocytes, with dopamine receptor D4 as a potential target for osteoarthritis treatment.
bioRxiv · Mar 10, 2023Pharmacology & Toxicology