Author

T. J. Kean

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Bioengineering· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:human· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Research Focus:clustering· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

J. E. Dennis· 3 shared M. A. Cruz· 3 shared M. Karimzadeh· 3 shared K. Martyniak· 2 shared R. J. Fernandes· 2 shared R. Medam· 2 shared T. Splawn· 2 shared A. Rubbo· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersCell Biology

J. E. Dennis

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Disease Modifying Osteoarthritis Drug Discovery Using A Temporal Phenotypic Reporter In Primary Human Chondrocytes

M. A. Cruz, S. Gronowicz, M. Karimzadeh, K. Martyniak, R. Medam, T. J. Kean

The paper identifies aromoline as a novel drug candidate that increases type II collagen in primary human chondrocytes, with dopamine receptor D4 as a potential target for osteoarthritis treatment.

bioRxiv · Mar 10, 2023Pharmacology & Toxicology

Micronutrient Optimization Using Design of Experiments Approach in Tissue Engineered Articular Cartilage for Production of Type II Collagen

M. A. Cruz, Y. Gonzalez, J. V. Toro, M. Karimzadeh, A. Rubbo, L. Morris, R. Medam, T. Splawn, M. Archer, R. J. Fernandes, J. E. Dennis, T. J. Kean

This study uses a Design of Experiments approach with a secreted reporter to optimize micronutrient conditions for enhanced type II collagen expression in engineered cartilage.

bioRxiv · Dec 7, 2022 · PreprintCell Biology

Optimizing bioink composition for human chondrocyte expression of lubricin

K. Martyniak, S. Kennedy, M. A. Cruz, M. Karimzadeh, O. Jeon, E. Alsberg, T. J. Kean

This study identifies an optimal bioink composition for enhancing lubricin expression in human chondrocytes using a high-throughput reporter system and 3D bioprinting.

bioRxiv · Nov 14, 2022Bioengineering

Physioxia stimulates extra-cellular matrix deposition and increases mechanical properties of human chondrocyte-derived tissue-engineered cartilage

J. E. Dennis, G. A. Whitney, J. Rai, R. J. Fernandes, T. J. Kean

This study shows that culturing human chondrocyte-derived cartilage under physiological oxygen tension increases extracellular matrix components and mechanical properties.

bioRxiv · Aug 5, 2020Cell Biology

High-throughput, temporal and dose dependent, effect of vitamins and minerals on chondrogenesis

J. E. Dennis, T. Splawn, T. J. Kean

The paper assesses the effect of vitamins and minerals on chondrogenesis using a high-throughput platform and identifies optimal combinations that enhance type II collagen expression.

bioRxiv · Oct 21, 2019Cell Biology