Author

R. Medam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

M. A. Cruz· 2 shared M. Karimzadeh· 2 shared T. J. Kean· 2 shared A. Rubbo· 1 shared J. E. Dennis· 1 shared J. V. Toro· 1 shared K. Martyniak· 1 shared L. Morris· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersPharmacology & Toxicology

M. A. Cruz

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2 papers

Recent·Most cited

Disease Modifying Osteoarthritis Drug Discovery Using A Temporal Phenotypic Reporter In Primary Human Chondrocytes

M. A. Cruz, S. Gronowicz, M. Karimzadeh, K. Martyniak, R. Medam, T. J. Kean

The paper identifies aromoline as a novel drug candidate that increases type II collagen in primary human chondrocytes, with dopamine receptor D4 as a potential target for osteoarthritis treatment.

bioRxiv · Mar 10, 2023Pharmacology & Toxicology

Micronutrient Optimization Using Design of Experiments Approach in Tissue Engineered Articular Cartilage for Production of Type II Collagen

M. A. Cruz, Y. Gonzalez, J. V. Toro, M. Karimzadeh, A. Rubbo, L. Morris, R. Medam, T. Splawn, M. Archer, R. J. Fernandes, J. E. Dennis, T. J. Kean

This study uses a Design of Experiments approach with a secreted reporter to optimize micronutrient conditions for enhanced type II collagen expression in engineered cartilage.

bioRxiv · Dec 7, 2022 · PreprintCell Biology