Author

M. A. Cruz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 3 Biochemistry· 1 Bioengineering· 1 Cell Biology· 1 Ecology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Research Focus:development & morphogenesis· 2 Research Focus:ecology & biodiversity· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

F. Zele· 4 shared S. Magalhaes· 4 shared I. Fragata· 3 shared M. Karimzadeh· 3 shared T. J. Kean· 3 shared D. P. Godinho· 2 shared K. Martyniak· 2 shared L. R. Rodrigues· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersEvolutionary Biology

F. Zele

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Competition for food affects the strength of reproductive interference and its consequences for species coexistence.

M. A. Cruz, O. Godoy, I. Fragata, V. C. Sousa, S. Magalhaes, F. Zele

This study shows that food competition alters reproductive interference between spider mite species, affecting their competitive outcomes and coexistence.

bioRxiv · Nov 9, 2023Ecology

Evolution in response to an abiotic stress shapes species coexistence

I. Fragata, D. P. Godinho, L. R. Rodrigues, M. A. Cruz, F. Zele, O. Godoy, S. Magalhaes

The paper shows that evolution in a stressful environment allows two spider mite species to coexist, but evolution of one species in isolation leads to exclusion.

bioRxiv · May 6, 2023Evolutionary Biology

Disease Modifying Osteoarthritis Drug Discovery Using A Temporal Phenotypic Reporter In Primary Human Chondrocytes

M. A. Cruz, S. Gronowicz, M. Karimzadeh, K. Martyniak, R. Medam, T. J. Kean

The paper identifies aromoline as a novel drug candidate that increases type II collagen in primary human chondrocytes, with dopamine receptor D4 as a potential target for osteoarthritis treatment.

bioRxiv · Mar 10, 2023Pharmacology & Toxicology

Micronutrient Optimization Using Design of Experiments Approach in Tissue Engineered Articular Cartilage for Production of Type II Collagen

M. A. Cruz, Y. Gonzalez, J. V. Toro, M. Karimzadeh, A. Rubbo, L. Morris, R. Medam, T. Splawn, M. Archer, R. J. Fernandes, J. E. Dennis, T. J. Kean

This study uses a Design of Experiments approach with a secreted reporter to optimize micronutrient conditions for enhanced type II collagen expression in engineered cartilage.

bioRxiv · Dec 7, 2022 · PreprintCell Biology

Optimizing bioink composition for human chondrocyte expression of lubricin

K. Martyniak, S. Kennedy, M. A. Cruz, M. Karimzadeh, O. Jeon, E. Alsberg, T. J. Kean

This study identifies an optimal bioink composition for enhancing lubricin expression in human chondrocytes using a high-throughput reporter system and 3D bioprinting.

bioRxiv · Nov 14, 2022Bioengineering

Wolbachia and host intrinsic reproductive barriers contribute additively to post-mating isolation in spider mites

M. A. Cruz, S. Magalhaes, E. Sucena, F. Zele

This study shows that Wolbachia-induced and host-associated incompatibilities act additively to reduce hybrid production in spider mites, with host factors having a greater impact.

bioRxiv · Jun 29, 2020Evolutionary Biology

Creating outbred and inbred populations of haplodiploid mites to measure adaptive responses in the lab

D. P. Godinho, M. A. Cruz, M. C. de la Masseliere, J. Teodoro-Paulo, C. Eira, I. Fragata, L. R. Rodrigues, F. Zele, S. Magalhaes

The paper describes methods to create outbred and inbred haplodiploid spider mite populations for studying adaptive responses and heritability.

bioRxiv · Feb 22, 2020 · PreprintEvolutionary Biology

A cryptic pocket in Ebola VP35 allosterically controls RNA binding

M. A. Cruz, T. E. Frederick, U. L. Mallimadugula, S. Singh, N. Vithani, M. I. Zimmerman, J. R. Porter, K. E. Moeder, G. K. Amarasinghe, G. R. Bowman

This study identifies a cryptic pocket in Ebola VP35 that allosterically controls RNA binding, validated through simulations, experiments, and drug-like modifications.

bioRxiv · Feb 9, 2020Biochemistry