M. Karimzadeh

Integrative identification of non-coding regulatory regions driving metastatic prostate cancer

This study identifies non-coding regulatory regions driving metastatic prostate cancer using an integrative computational and experimental approach.

Disease Modifying Osteoarthritis Drug Discovery Using A Temporal Phenotypic Reporter In Primary Human Chondrocytes

The paper identifies aromoline as a novel drug candidate that increases type II collagen in primary human chondrocytes, with dopamine receptor D4 as a potential target for osteoarthritis treatment.

Micronutrient Optimization Using Design of Experiments Approach in Tissue Engineered Articular Cartilage for Production of Type II Collagen

This study uses a Design of Experiments approach with a secreted reporter to optimize micronutrient conditions for enhanced type II collagen expression in engineered cartilage.

Optimizing bioink composition for human chondrocyte expression of lubricin

This study identifies an optimal bioink composition for enhancing lubricin expression in human chondrocytes using a high-throughput reporter system and 3D bioprinting.

Single-cell profiling of healthy human kidney reveals features of sex-based transcriptional programs and tissue-specific immunity

This study profiles healthy human kidney cells from 19 donors to reveal sex-based transcriptional differences and tissue-specific immune features.

Multiscale interactome analysis coupled with off-target drug predictions reveals drug repurposing candidates for human coronavirus disease

Experimental and natural evidence of SARS-CoV-2 infection-induced activation of type I interferon responses

This study shows SARS-CoV-2 infection induces a mild type I IFN response in vitro and in moderate COVID-19 cases, and cannot inhibit exogenous IFN induction.

Human papillomavirus integration transforms chromatin to drive oncogenesis

This study shows HPV integration introduces CTCF binding sites, altering chromatin and upregulating essential genes in HPV+ cancers.