B. N. Finck

Glucocorticoid intermittence coordinates rescue of energy and mass in aging-related sarcopenia through the myocyte-autonomous PGC1alpha-Lipin1 transactivation

This study shows that intermittent glucocorticoid treatment rescues both energy and mass in aging-related sarcopenia via the PGC1alpha-Lipin1 pathway in muscle cells.

Disruption of Hepatic Mitochondrial Pyruvate and Amino Acid Metabolism Impairs Gluconeogenesis and Endurance Exercise Capacity in Mice

Effects of hepatic mitochondrial pyruvate carrier deficiency on de novo lipogenesis and glycerol-mediated gluconeogenesis in mice

This study investigates how liver mitochondrial pyruvate carrier deficiency affects de novo lipogenesis and glycerol-mediated gluconeogenesis in mice, finding impaired DNL but no reduction in intrahepatic lipid and unchanged glucose levels despite reduced glycerol metabolism.

Mitochondrial Pyruvate Carrier Inhibition Attenuates Hepatic Stellate Cell Activation and Liver Injury in a Mouse Model of Metabolic Dysfunction-associated Steatotic Liver Disease

Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult in mice

This study shows that loss of both MPC and ALT2 increases susceptibility to oxidative stress and worsens liver injury in mice, while ALT2 induction reduces APAP toxicity.

Mitochondrial Pyruvate Carrier Inhibition Initiates Metabolic Crosstalk to Stimulate Branched Chain Amino Acid Catabolism

This study shows that inhibiting the mitochondrial pyruvate carrier reduces branched chain amino acid (BCAA) levels and phosphorylation of BCKDH by activating AMPK/mTOR signaling in patients with NASH and in vitro models.

Silencing alanine transaminase 2 in diabetic liver attenuates hyperglycemia by reducing gluconeogenesis from amino acids

This study shows that silencing ALT2 in diabetic liver reduces hyperglycemia by decreasing amino acid-derived gluconeogenesis.

Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk

This study shows exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic IL-6 signaling through inter-organ crosstalk, but does not enhance liver regeneration.

Antisense oligonucleotides against monoacylglycerol acyltransferase 1 (Mogat1) improve glucose metabolism independently of Mogat1

This study shows that Mogat1 ASOs improve glucose metabolism in mice independently of Mogat1 knockdown or IFNAR-1 activation.

Lipin-1 regulates lipid catabolism in pro-resolving macrophages.

This study shows lipin-1 regulates lipid catabolism in pro-resolving macrophages by promoting fatty acid oxidation and TCA cycle function during IL-4 responses.

Macrophage-associated lipin-1 transcriptional co-regulatory activity is involved in atherosclerosis

This study shows that lipin-1's transcriptional co-regulatory activity protects against atherosclerosis, while its enzymatic activity promotes it, using a mouse model with myeloid cell-specific lipin-1 deletion.

Ketogenic Diet Prevents Heart Failure from Defective Mitochondrial Pyruvate Metabolism

This study shows that a ketogenic diet prevents heart failure in mice with defective mitochondrial pyruvate metabolism by reversing cardiac remodeling and dysfunction.

Lipin-1 contributes to IL-4 mediated macrophage polarization

This study shows that lipin-1's transcriptional co-regulator activity is necessary for macrophage polarization and wound healing, as its absence impairs IL-4 mediated gene expression and tissue repair.

NADPH and glutathione redox link TCA cycle activity to endoplasmic reticulum stress

The paper shows that TCA cycle activity influences ER stress via NADPH and glutathione redox metabolism in mouse hepatocytes.