Large Neutral Amino acid uptake and mTOR activation within CD4+ T cells coordinate Type 2 immunity and host resistance to Trichuris muris
M. Z. Krauss, K. S. Hayes, A. Villegas-Mendez, M. R. Hepworth, L. V. Sinclair, K. N. Couper, R. K. Grencis
This study shows that SLC7A5-mediated mTOR activation in CD4+ T cells is essential for effective Type 2 immunity and resistance to T. muris infection.
bioRxiv · Nov 30, 2020Immunology