Author
M. R. Hepworth
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Biology Disciplines
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2020-2023 · peak 3/yrCo-Author Collaboration Network
10 top collaborators · 14 mutual co-author links8 papers
Recent·Most cited
- ImmunologybioRxiv
Rapid establishment of a tumor-retained state curtails the contribution of conventional NK cells to anti-tumor immunity in solid cancers
I. W. Dean, C. Y. Lee, Z. K. Tuong…·D. R. Withers
This study shows that conventional NK cells rapidly lose effector functions upon entering tumors and that IL-15:IL-15Ra complexes can restore their function and tissue-residency.
- ImmunologybioRxiv
Bcl2 supports survival and metabolic fitness of quiescent tissue-resident ILC3
J. I. King, F. Melo-Gonzalez, B. Malengier-Devlies…·M. R. Hepworth
This study shows Bcl2 supports survival and metabolic fitness of quiescent tissue-resident ILC3 in the gut, independent of haematopoietic replenishment.
DOI 10.1016/j.mucimm.2023.07.001 - ImmunologybioRxivPreprint
Distinct eosinophil subsets are modulated by agonists of the commensal-metabolite and vitamin B3 receptor GPR109A during allergic-type inflammation
R. Azzoni, K. J. Filbey, R. H. Daw…·J. R. Grainger
The paper identifies GPR109A as a regulator of glycolytic Siglec-Fhi eosinophils during allergic inflammation, showing that GPR109A ligands reduce their frequency and activation.
DOI 10.1101/2022.08.04.502285 - ImmunologybioRxiv
Rhythmicity of Intestinal IgA Responses Confers Oscillatory Commensal Microbiota Mutualism
H. A. Penny, R. G. Domingues, M. Z. Krauss…·M. R. Hepworth
This study shows diurnal rhythms in intestinal IgA regulate oscillations in commensal microbiota abundance, promoting mutualism.
DOI 10.1126/sciimmunol.abk2541 - ImmunologybioRxiv
Metabolic regulation of ILC2 differentiation into ILC1-like cells during Mycobacterium tuberculosis infection
D. Hudrisier, D. Corral, A. Charton…·O. Neyrolles
This study shows that Mycobacterium tuberculosis infection drives immature lung ILC2 to differentiate into ILC1-like cells through type 1 cytokines and a glycolytic program controlled by HIF1.
DOI 10.1016/j.celrep.2022.110715 - ImmunologybioRxiv
The skin environment controls local dendritic cell differentiation and function through innate IL-13
J. U. Mayer, O. Lamiable, K. L. Hilligan…·F. Ronchese
This study shows that IL-13 signaling via STAT6 and KLF4 controls dermal DC2 differentiation and function, shaping a non-inflammatory, pro-allergic skin environment.
- ImmunologybioRxiv
Large Neutral Amino acid uptake and mTOR activation within CD4+ T cells coordinate Type 2 immunity and host resistance to Trichuris muris
M. Z. Krauss, K. S. Hayes, A. Villegas-Mendez…·R. K. Grencis
This study shows that SLC7A5-mediated mTOR activation in CD4+ T cells is essential for effective Type 2 immunity and resistance to T. muris infection.
DOI 10.1093/discim/kyag003