Formate induces a metabolic switch in nucleotide and energy metabolism
K. Oizel, J. Tait-Mulder, J. Fernandez-de-Cossio-Diaz, M. Pietzke, H. Brunton, S. Dhayade, D. Athineos, S. Lilla, G. Rodriguez Blanco, D. Sumpton, G. M. Mackay, K. Blyth, S. Zanivan, J. Meiser, A. Vazquez
This study shows formate induces a metabolic switch increasing adenine nucleotides, glycolysis, and repressing AMPK, with implications for cancer metabolism.
bioRxiv · Aug 16, 2019Biochemistry