Author

S. Dhayade

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cancer & tumor microenvironment· 4 Organism:mouse· 4 Assay:metabolomics· 3 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

K. Blyth· 5 shared D. Sumpton· 4 shared D. Athineos· 3 shared S. Zanivan· 3 shared C. Jamieson· 2 shared J. Tait-Mulder· 2 shared M. Pietzke· 2 shared S. B. Coffelt· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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5 shared papersCancer Biology

K. Blyth

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Author profile →

5 papers

Recent·Most cited

Metabolic adaptations of micrometastases alter EV production to generate invasive microenvironments

M. Gounis, A. Campos, E. Shokry, L. Mitchell, E. Dornier, N. Rooney, S. Dhayade, L. Pardo, M. Moore, D. Novo, J. Mowat, C. Jamieson, E. Kay, S. Zanivan, C. Nixon, , C. Clarke

The paper shows that breast cancer micrometastases alter metabolism to change extracellular vesicle production, creating an invasive microenvironment.

bioRxiv · May 12, 2024Cancer Biology

PYCR1-dependent proline synthesis in cancer-associated fibroblasts is required for the deposition of pro-tumorigenic extracellular matrix

E. J. Kay, K. Paterson, C. Riero Domingo, D. Sumpton, H. Daebritz, S. Tardito, C. Boldrini, J. R. Hernandez-Fernaud, D. Athineos, S. Dhayade, E. Stepanova, E. Gjerga, L. J. Neilson, S. Lilla, A. Hedley, , S. Zanivan

This study identifies PYCR1-dependent proline synthesis in cancer-associated fibroblasts as critical for collagen production and tumor progression, suggesting PYCR1 as a therapeutic target to inhibit pro-tumorigenic extracellular matrix deposition.

bioRxiv · May 30, 2020 · PreprintCancer Biology

Impact of formate supplementation on body weight and plasma amino acids

S. Dhayade, M. Pietzke, R. Wiesheu, J. Tait-Mulder, D. Athineos, D. Sumpton, S. B. Coffelt, K. Blyth, A. B. Vazquez

This study examines the effects of sodium formate supplementation on body weight, plasma amino acids, and gut microbiota in mice, finding significant changes in females but not males.

bioRxiv · May 4, 2020Biochemistry

The MSP-RON axis stimulates cancer cell growth in models of triple negative breast cancer

R. Millar, A. Kilbey, S.-J. Remak, T. M. Severson, S. Dhayade, E. Sandilands, K. Foster, D. M. Bryant, K. Blyth, S. B. Coffelt

This study identifies the MSP-RON axis as a driver of TNBC growth in a mouse model and shows that inhibiting RON reduces tumor progression.

bioRxiv · Feb 19, 2020Cancer Biology

Formate induces a metabolic switch in nucleotide and energy metabolism

K. Oizel, J. Tait-Mulder, J. Fernandez-de-Cossio-Diaz, M. Pietzke, H. Brunton, S. Dhayade, D. Athineos, S. Lilla, G. Rodriguez Blanco, D. Sumpton, G. M. Mackay, K. Blyth, S. Zanivan, J. Meiser, A. Vazquez

This study shows formate induces a metabolic switch increasing adenine nucleotides, glycolysis, and repressing AMPK, with implications for cancer metabolism.

bioRxiv · Aug 16, 2019Biochemistry