Author

L. I. James

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:ATAC-seq· 1 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

A.-M. Turner· 2 shared A. Detappe· 1 shared B. Bragantini· 1 shared D. Chowdhury· 1 shared D. J. Schuller· 1 shared D. M. Margolis· 1 shared D. Margolis· 1 shared E. P. Browne· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersMicrobiology

A.-M. Turner

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering

G. Cui, M. V. Botuyan, P. Drane, Q. Hu, B. Bragantini, J. R. Thompson, D. J. Schuller, A. Detappe, M. T. Perfetti, L. I. James, S. V. Frye, D. Chowdhury, G. Mer

This study identifies an autoinhibited state of 53BP1 stabilized by small molecule ligands, which shift its conformational equilibrium and inhibit chromatin recruitment.

bioRxiv · Apr 20, 2023Biochemistry

Epigenomic characterization of latent HIV infection identifies latency regulating transcription factors.

S. R. Jefferys, S. D. Burgos, J. Peterson, S. R. Selitsky, A.-M. Turner, L. I. James, D. M. Margolis, J. Parker, E. P. Browne

This study identifies transcription factors regulating HIV latency through epigenomic analysis of latently infected cells.

PLOS Pathogens · Feb 26, 2021Peer-reviewedMicrobiology

Degradation of Polycomb Repressive Complex 2 with an EED-targeted Bivalent Chemical Degrader

F. Potjewyd, A.-M. Turner, J. Beri, J. Rectenwald, J. Norris-Drouin, S. Cholensky, D. Margolis, K. Pearce, L. Herring, L. I. James

This paper introduces a bivalent chemical degrader, UNC6852, that targets PRC2 components and demonstrates its ability to degrade PRC2 and inhibit EZH2 activity in cancer cells.

bioRxiv · Jun 21, 2019Cancer Biology