Author

K. Pennel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

J. Edwards· 3 shared C. Nixon· 2 shared J. Hay· 2 shared O. J. Sansom· 2 shared A. Biankin· 1 shared A. Cameron· 1 shared A. D. Campbell· 1 shared A. Legrini· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersCancer Biology

J. Edwards

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Author profile →

3 papers

Recent·Most cited

WNT Signalling Promotes NF-κB Activation and Drug Resistance in KRAS-Mutant Colorectal Cancer

B. Cong, E. Stamou, K. Pennel, M. McKenzie, A. Matly, J. Edwards, R. Cagan

This study shows that WNT signaling enhances NF-κB activation and drug resistance in KRAS-mutant colorectal cancer, suggesting a therapeutic strategy targeting WNT and MEK pathways.

bioRxiv · Dec 21, 2023Cancer Biology

eIF4A1 is essential for reprogramming the translational landscape of Wnt-driven colorectal cancers

J. A. Waldron, G. Kanellos, R. C. L. Smith, J. R. P. Knight, J. Munro, C. Alexandrou, N. Vlahov, L. Pardo-Fernandez, M. Moore, S. L. Gillen, D. Strathdee, D. Stevenson, F. C. Warrander, K. Gilroy, C. Nixon, , O. J. Sansom

This study shows eIF4A1 is critical for supporting translational demands in Wnt-driven colorectal cancers, while eIF4A2 loss accelerates tumourigenesis, and eFT226 inhibits eIF4A1 function in these models.

bioRxiv · Nov 10, 2023 · PreprintCancer Biology

Spatially Resolved Transcriptomics Deconvolutes Histological Prognostic Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases

C. S. Wood, K. Pennel, H. Leslie, A. Legrini, A. Cameron, L. Melissourgou-Syka, J. Quinn, H. Van Wyk, J. Hay, A. Roseweir, C. Nixon, C. Roxburgh, D. McMillan, A. Biankin, O. J. Sansom, , N. Jamieson

This study uses spatial transcriptomics to identify prognostic immune and stromal subgroups in colorectal cancer liver metastases, revealing distinct transcriptomic programs associated with survival outcomes.

bioRxiv · Sep 21, 2022 · PreprintCancer Biology