T cells instruct dendritic cells to produce inflammasome independent IL-1β causing systemic inflammation
A. Jain, R. A. Irizarry-Caro, A. S. Chawla, N. H. Philip, K. R. Carroll, J. Katz, A. Oberst, A. Chervonsky, C. Pasare
This study identifies a T cell-instructed, inflammasome-independent pathway of IL-1β production in dendritic cells that drives systemic inflammation in autoimmune diseases.
bioRxiv · Nov 26, 2018 · PreprintImmunology