Molecularly barcoded Zika virus libraries to probe in vivo evolutionary dynamics
M. T. Aliota, D. M. Dudley, C. M. Newman, J. Weger-Lucarelli, L. M. Stewart, M. R. Koenig, M. E. Breitbach, A. M. Weiler, M. R. Semler, G. L. Barry, K. R. Zarbock, M. S. Mohns, E. L. Mohr, V. Venturi, N. Schultz-Darken, , D. H. O'Connor
This paper uses molecularly barcoded Zika virus to study in vivo infection dynamics in pregnant and non-pregnant macaques and mosquitoes, finding stable lineage proportions during acute infection but a rapid decline in complexity post-infection in pregnant animals.
bioRxiv · Nov 17, 2017Microbiology