M. R. Koenig

Vertical transmission of African-lineage Zika virus through the fetal membranes in a rhesus Macaque (Macaca mulatta) model

This study shows ZIKV can transmit vertically through fetal membranes, not the placenta, in rhesus macaques.

Infection of the maternal-fetal interface and vertical transmission following low-dose inoculation of pregnant rhesus macaques (Macaca mulatta) with an African-lineage Zika virus

This study shows African-lineage Zika virus can be vertically transmitted to rhesus macaque fetuses with a low dose, similar to Asian-lineage viruses.

Quantitative definition of neurobehavior, vision, hearing and brain volumes in macaques congenitally exposed to Zika virus

The paper assesses the feasibility of using a macaque model to study neurodevelopmental deficits from congenital Zika virus exposure and estimates required sample sizes for future studies.

Long-term protection of rhesus macaques from Zika virus reinfection

This study shows that rhesus macaques retain neutralizing antibodies against ZIKV for at least 27 months, protecting them from detectable plasma viremia upon rechallenge.

Primary infection with dengue or Zika virus does not affect the severity of heterologous secondary infection in macaques.

This study investigates whether prior dengue or Zika virus infection affects the severity of subsequent heterologous secondary infections in macaques, finding no significant impact on clinical outcomes.

Molecularly barcoded Zika virus libraries to probe in vivo evolutionary dynamics

This paper uses molecularly barcoded Zika virus to study in vivo infection dynamics in pregnant and non-pregnant macaques and mosquitoes, finding stable lineage proportions during acute infection but a rapid decline in complexity post-infection in pregnant animals.