D. M. Dudley

Frequent first-trimester pregnancy loss in rhesus macaques infected with African-lineage Zika virus

This study shows that African-lineage ZIKV infection in early first trimester causes high pregnancy loss in rhesus macaques, regardless of SIV status.

Fetal loss in pregnant rhesus macaques infected with high-dose African-lineage Zika virus

This study shows that high-dose African-lineage Zika virus infection in late first trimester pregnant rhesus macaques causes frequent fetal loss.

Zika virus persistence in the male macaque reproductive tract

This study investigates ZIKV persistence in male macaque reproductive tissues, finding prolonged viral presence in germ and epithelial cells and potential impacts on fertility.

Early embryonic loss following intravaginal Zika virus challenge in rhesus macaques

This study infects rhesus macaques intravaginally with Zika virus and finds that two of three pregnancies resulted in early embryonic loss with viral RNA detected at the maternal-fetal interface.

Prior dengue immunity enhances Zika virus infection of the maternal-fetal interface in rhesus macaques

This study shows that prior dengue virus immunity enhances Zika virus infection at the maternal-fetal interface in rhesus macaques but does not affect plasma replication or fetal outcomes.

Quantitative definition of neurobehavior, vision, hearing and brain volumes in macaques congenitally exposed to Zika virus

The paper assesses the feasibility of using a macaque model to study neurodevelopmental deficits from congenital Zika virus exposure and estimates required sample sizes for future studies.

High-throughput identification of MHC class I binding peptides using an ultradense peptide array

This paper uses an ultradense peptide array to identify MHC class I binding peptides, finding 64% of known epitopes and three novel ones in rhesus macaques.

Long-term protection of rhesus macaques from Zika virus reinfection

This study shows that rhesus macaques retain neutralizing antibodies against ZIKV for at least 27 months, protecting them from detectable plasma viremia upon rechallenge.

Primary infection with dengue or Zika virus does not affect the severity of heterologous secondary infection in macaques.

This study investigates whether prior dengue or Zika virus infection affects the severity of subsequent heterologous secondary infections in macaques, finding no significant impact on clinical outcomes.

Molecularly barcoded Zika virus libraries to probe in vivo evolutionary dynamics

This paper uses molecularly barcoded Zika virus to study in vivo infection dynamics in pregnant and non-pregnant macaques and mosquitoes, finding stable lineage proportions during acute infection but a rapid decline in complexity post-infection in pregnant animals.

Ocular and uteroplacental pathology in macaque congenital Zika virus infection

This study reports ocular and uteroplacental pathology in rhesus macaques infected with ZIKV during pregnancy, showing prolonged viral replication and severe fetal outcomes.

Highly Efficient Maternal-Fetal Zika Virus Transmission in Pregnant Rhesus Macaques

This study infects pregnant rhesus macaques with ZIKV and observes prolonged maternal viremia and fetal tissue infection, indicating efficient vertical transmission.

Oropharyngeal mucosal transmission of Zika virus in rhesus macaques

This study assesses the risk of Zika virus transmission through mucosal contact in rhesus macaques, finding that oral secretions from infected individuals pose a low transmission risk.