Author

K. Rittinger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

A. P. Snijders· 1 shared A. Powell· 1 shared A. Vuorinen· 1 shared B. Simon· 1 shared B. Stieglitz· 1 shared C. R. Kennedy· 1 shared D. House· 1 shared F. Gabel· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperBiochemistry

A. P. Snijders

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3 papers

Recent·Most cited

A chemoproteomic platform for reactive fragment profiling against the deubiquitinases

R. Cookson, A. Vuorinen, J. Pettinger, C. R. Kennedy, J. M. Kirkpatrick, R. E. Peltier-Heap, A. Powell, A. P. Snijders, M. Skehel, D. House, K. Rittinger, J. T. Bush

The paper develops a chemoproteomics workflow to screen covalent fragments against DUB enzymes, validating four hits using biochemical assays.

bioRxiv · Feb 1, 2023 · PreprintBiochemistry

Structural basis for ubiquitylation by HOIL-1

Q. Wu, M. G. Koliopoulos, K. Rittinger, B. Stieglitz

This study determines the crystal structure of HOIL-1's C-terminal tandem domain, revealing its auto-inhibited conformation and the role of a unique bi-nuclear Zn-cluster in ubiquitylation.

bioRxiv · Nov 13, 2022Biochemistry

Mechanistic insights into RNA binding and RNA-regulated RIG-I ubiquitination by TRIM25

K. Haubrich, S. Augsten, L. Alvarez, I. Huppertz, B. Simon, K. Perez, P. Masiewicz, M. Lethier, K. Rittinger, F. Gabel, M. W. Hentze, S. Cusack, J. Hennig

This study identifies RNA binding sites on TRIM25 and shows that RNA binding enhances its E3 ligase activity and affects RIG-I ubiquitination.

bioRxiv · May 4, 2020 · PreprintMolecular Biology