Author

D. House

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. Powell· 2 shared A. Claessens· 1 shared A. G. Purkiss· 1 shared A. P. Snijders· 1 shared A. Vuorinen· 1 shared C. R. Kennedy· 1 shared C. R. Landry· 1 shared D. A. Jones· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersMicrobiology

A. Powell

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Evolution and inhibition of the FIKK effector kinase family in P. falciparum

H. Belda, D. Bradley, E. Christodoulou, S. D. Nofal, M. Broncel, D. A. Jones, H. Davies, M. T. Bertran, A. G. Purkiss, R. W. Ogrodowicz, D. Joshi, N. O'Reilly, L. Walport, A. Claessens, A. Powell, , M. Treeck

This study investigates the evolution and inhibition of FIKK kinases in P. falciparum, showing they can be inhibited by a single compound.

bioRxiv · Feb 22, 2024 · PreprintMicrobiology

A chemoproteomic platform for reactive fragment profiling against the deubiquitinases

R. Cookson, A. Vuorinen, J. Pettinger, C. R. Kennedy, J. M. Kirkpatrick, R. E. Peltier-Heap, A. Powell, A. P. Snijders, M. Skehel, D. House, K. Rittinger, J. T. Bush

The paper develops a chemoproteomics workflow to screen covalent fragments against DUB enzymes, validating four hits using biochemical assays.

bioRxiv · Feb 1, 2023 · PreprintBiochemistry

Novel MOG analogues to explore the MCT2 pharmacophore, α-ketoglutarate biology and cellular effects of N-oxalylglycine

L. Fets, N. Bevan, P. M. Nunes, S. Campos, M. Silva dos Santos, E. B. Sherriff, J. I. MacRae, D. House, D. Anastasiou

The paper designs and characterizes MOG analogues to study MCT2 pharmacophore, KG biology, and cellular effects of NOG, showing compounds that inhibit PHDs without cytotoxicity.

bioRxiv · Mar 15, 2021Biochemistry