Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
8 papers
Recent·Most cited
A. Roeselova, S. L. Maslen, S. Shivakumaraswamy, G. A. Pellowe, S. Howell, D. Joshi, J. Redmond, S. Kjaer, M. Skehel, D. Balchin
The paper investigates how chaperones coordinate during cotranslational protein folding in bacteria, showing they create a protected space for maturation without destabilizing intermediates.
Molecular Cell · Jul 1, 2024Peer-reviewedBiochemistry
K. Koussis, S. Haase, C. Withers-Martinez, H. R. Flynn, S. Kunzelmann, E. Christodoulou, F. Ibrahim, M. Skehel, D. A. Baker, M. J. Blackman
This study shows that PKG regulation in malaria parasites involves cGMP saturation and activation loop phosphorylation, with phosphorylation being essential for in vivo function.
bioRxiv · Feb 4, 2024Microbiology
R. Cookson, A. Vuorinen, J. Pettinger, C. R. Kennedy, J. M. Kirkpatrick, R. E. Peltier-Heap, A. Powell, A. P. Snijders, M. Skehel, D. House, K. Rittinger, J. T. Bush
The paper develops a chemoproteomics workflow to screen covalent fragments against DUB enzymes, validating four hits using biochemical assays.
bioRxiv · Feb 1, 2023 · PreprintBiochemistry
E. Gonzalez-Rodriguez, M. Zol-Hanlon, G. Bineva-Todd, A. Marchesi, M. Skehel, K. Mahoney, C. Roustan, A. Borg, L. Di Vagno, S. Kjaer, A. G. Wrobel, D. J. Benton, P. Nawrath, S. L. Flitsch, D. Joshi, , B. Schumann
This paper shows that O-linked sialoglycans affect SARS-CoV-2 spike proteolysis by furin and TMPRSS2, and may drive mutations in variants of concern.
bioRxiv · Sep 15, 2022Cell Biology
R. L. Williams, M. Heimhalt, A. Berndt, J. L. Wagstaff, M. Anandapadamanaban, O. Perisic, S. Maslen, S. H. McLaughlin, C. W.-H. Yu, G. R. Masson, A. Boland, X. Ni, K. Yamashita, G. N. Murshudov, M. Skehel, S. M. Freund
This study investigates the interaction between DEPTOR and mTORC1, revealing DEPTOR as a partial inhibitor that is more effective against activated mTORC1, with mutual antagonism mediated by phosphorylation and structural interactions.
bioRxiv · Apr 28, 2021Biochemistry
M. Artan, S. Barratt, S. M. Flynn, F. Begum, M. Skehel, A. Nicolas, M. de Bono
The paper optimizes a TurboID proximity labeling protocol for C. elegans to characterize tissue and synaptic proteomes, identifying both known and novel proteins.
bioRxiv · Apr 1, 2021Biochemistry
D. Baretic, M. Jenkyn-Bedford, V. Aria, G. Cannone, M. Skehel, J. T. P. Yeeles
The paper presents cryo-EM structures of the replisome components CMG, Ctf4, Csm3/Tof1, and Mrc1 bound to a replication fork, revealing their interactions and mechanisms in DNA replication and fork stabilization.
bioRxiv · Dec 18, 2019Biochemistry
Y. Tsuchiya, D. Byrne, S. Burgess, J. Bormann, J. Bakovic, Y. Huang, A. Zhyvoloup, S. Peak-Chew, T. Tran, F. Bellany, A. Tabor, E. Chan, L. Guruprasad, O. Garifulin, V. Filonenko, , I. Gout
This study identifies a novel covalent inhibition mechanism of Aurora A kinase by coenzyme A, showing its regulation under oxidative stress and impact on meiotic spindle formation.
bioRxiv · Nov 14, 2018Biochemistry