Author

J. M. Kirkpatrick

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 4

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Assay:proteomics· 4 Research Focus:cell type annotation· 3 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Ori· 2 shared A. Bartolome· 1 shared A. Leheis· 1 shared A. Minetti· 1 shared A. P. Snijders· 1 shared A. Powell· 1 shared A. Vuorinen· 1 shared C. Marx· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

A. Ori

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A chemoproteomic platform for reactive fragment profiling against the deubiquitinases

R. Cookson, A. Vuorinen, J. Pettinger, C. R. Kennedy, J. M. Kirkpatrick, R. E. Peltier-Heap, A. Powell, A. P. Snijders, M. Skehel, D. House, K. Rittinger, J. T. Bush

The paper develops a chemoproteomics workflow to screen covalent fragments against DUB enzymes, validating four hits using biochemical assays.

bioRxiv · Feb 1, 2023 · PreprintBiochemistry

ProteasomeID: quantitative mapping of proteasome interactomes and substrates for in vitro and in vivo studies

A. Bartolome, J. C. Heiby, D. Di Fraia, I. Heinze, H. Knaudt, E. Spaeth, O. Omrani, A. Minetti, M. Hofmann, J. M. Kirkpatrick, T. Dau, A. Ori

This study develops a method to quantify proteasome interactomes and substrates in vivo using biotin ligases and a new mouse model, identifying novel interactors and substrates.

bioRxiv · Aug 9, 2022Biochemistry

Solvent Precipitation SP3 (SP4) enhances recovery for proteomics sample preparation without magnetic beads

H. E. Johnston, K. Yadav, J. M. Kirkpatrick, G. S. Biggs, D. Oxley, H. B. Kramer, R. S. Samant

This paper introduces SP4, a proteomics sample preparation method that replaces magnetic beads with solvent precipitation and centrifugation, improving protein recovery and reproducibility compared to SP3.

bioRxiv · Sep 24, 2021Biochemistry

Mapping sites of carboxymethyllysine modification on proteins reveals its consequences for proteostasis and cell proliferation

S. Di Sanzo, K. Spengler, A. Leheis, J. M. Kirkpatrick, T. L. Raendler, T. Baldensperger, L. Parca, C. Marx, Z. Q. Wang, M. A. Glomb, A. Ori, R. Heller, R. Heller

This study maps carboxymethyllysine (CML) modification sites on proteins in mouse and human cells, showing its impact on proteostasis and cell proliferation.

bioRxiv · Oct 16, 2020 · PreprintBiochemistry