A chemoproteomic platform for reactive fragment profiling against the deubiquitinases
R. Cookson, A. Vuorinen, J. Pettinger, C. R. Kennedy, J. M. Kirkpatrick, R. E. Peltier-Heap, A. Powell, A. P. Snijders, M. Skehel, D. House, K. Rittinger, J. T. Bush
The paper develops a chemoproteomics workflow to screen covalent fragments against DUB enzymes, validating four hits using biochemical assays.
bioRxiv · Feb 1, 2023 · PreprintBiochemistry