K. Ruis

NBS1 binds directly to TOPBP1 via disparate interactions between the NBS1 BRCT1 domain and the TOPBP1 BRCT1 and BRCT2 domains

This study identifies two distinct interaction sites between NBS1 and TOPBP1, showing direct binding through their BRCT domains without requiring intact domains or post-translational modifications.

Multi-site phosphorylation of the TOPBP1 ATR Activation Domain propels ATR signaling during the response to DNA breaks

This study identifies multi-site phosphorylation of the TOPBP1 ATR activation domain as critical for ATR activation during DNA damage response.