Y. Jami-Alahmadi

ACD15, ACD21, and SLN regulate accumulation and mobility of MBD6 to silence genes and transposable elements.

The paper shows ACD15 and ACD21 are essential for MBD5/6 complex accumulation and mobility, which silences genes and transposable elements in Arabidopsis.

Chikungunya virus glycoproteins transform macrophages into productive viral dissemination vessels.

This study identifies CHIKV glycoproteins E2 and E1 as key factors that enable macrophages to support viral replication and dissemination by counteracting host restriction factors.

Direct Tests of Cytochrome Function in the Electron Transport Chain of Malaria Parasites

This study investigates the function of two cytochrome c homologs in the mitochondrial electron transport chain of malaria parasites, revealing that one is essential while the other has unique structural properties and is not required for blood-stage growth.

Arabidopsis TRB proteins function in H3K4me3 demethylation by recruiting JMJ14

This study shows TRB proteins recruit JMJ14 to demethylate H3K4me3 and coordinate with PRC2 to repress target genes.

The MOM1 complex recruits the RdDM machinery via MORC6 to establish de novo DNA methylation.

The paper shows MOM1 recruits RdDM machinery via MORC6 to establish de novo DNA methylation and maintain chromatin state at RdDM sites.

MORC proteins regulate transcription factor binding by mediating chromatin compaction in active chromatin regions

The paper investigates RdDM-independent functions of MORC proteins, showing they compact chromatin and repress gene expression by reducing TF accessibility, especially under stress.

A gene silencing screen uncovers diverse tools for targeted gene repression in Arabidopsis

The paper identifies multiple proteins that can silence genes in Arabidopsis through various epigenetic mechanisms and develops a machine learning model to predict silencing efficacy.

Multi-site phosphorylation of the TOPBP1 ATR Activation Domain propels ATR signaling during the response to DNA breaks

This study identifies multi-site phosphorylation of the TOPBP1 ATR activation domain as critical for ATR activation during DNA damage response.

Histone chaperone ASF1 mediates H3.3-H4 deposition in Arabidopsis

This study shows that ASF1 in Arabidopsis preferentially interacts with the HIRA complex for H3.3-H4 deposition, affecting chromatin structure and gene regulation.

Transcriptional drifts associated with environmental changes in endothelial cells

The paper identifies transcriptional changes in endothelial cells due to environmental factors like shear stress and heterotypic interactions, showing their impact on gene expression independent of genetic background.

The Nse5/6-like SIMC1-SLF2 Complex Localizes SMC5/6 to Viral Replication Centers

This paper identifies SIMC1 and SLF2 as novel subunits forming Nse5/6-like complexes that regulate SMC5/6 localization to viral replication centers and DNA damage sites.

Substrate trapping approach identifies TRIM25 ubiquitination targets involved in diverse cellular and antiviral processes

The dynamics of HD-ZIP III - ZPR protein interactions play essential roles in embryogenesis, meristem function and organ development

This study investigates the roles of ZPR proteins in plant development by analyzing their interactions with HD-ZIP III transcription factors through genetics, imaging, and biochemistry.

Divergent Acyl Carrier Protein Decouples Mitochondrial Fe-S Cluster Biogenesis from Fatty Acid Synthesis in Malaria Parasites

This paper identifies a divergent acyl carrier protein in Plasmodium that couples mitochondrial Fe-S cluster biogenesis to the electron transport chain, independent of fatty acid synthesis.

Activation of FAM111A Protease Induces Defects in Nuclear Function that Likely Underlie its Roles in Disease and Viral Restriction

This study shows FAM111A protease mutants cause nuclear dysfunction linked to disease and viral restriction.

Wnt-inducible Lrp6-APEX2 Interacting Proteins identify ESCRT Machinery and Trk-Fused Gene as Components of the Wnt Signaling Pathway

This study identifies ESCRT machinery and TFG as components of the Wnt signaling pathway using APEX2 proximity labeling and proteomic analysis.

EXP1 is required for organization of the intraerythrocytic malaria parasite vacuole

This study investigates the role of EXP1 in maintaining the structure of the malaria parasite's parasitophorous vacuole using CRISPR/Cpf1 and BioID2, revealing its critical function in vacuole organization.

The plant mobile domain proteins MAIN and MAIL1 interact with the phosphatase PP7L to regulate gene expression and silence transposable elements in Arabidopsis thaliana.

The paper identifies an interaction between PMD proteins MAIN and MAIL1 with the phosphatase PP7L that regulates gene expression and silences transposable elements in Arabidopsis thaliana.