Author

J. Wohlschlegel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Plant Biology· 5 Cell Biology· 3 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:chromatin & epigenetic regulation· 6 Organism:Arabidopsis· 5 Assay:DNA methylation· 5 Assay:proteomics· 5 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Research Focus:gene regulatory network inference· 3

Frequent Co-Authors

Y. Jami-Alahmadi· 8 shared S. E. Jacobsen· 5 shared S. Feng· 4 shared J. Gallego-Bartolome· 3 shared J. Sha· 3 shared M. Wang· 3 shared Z. Zhong· 3 shared J. A. Long· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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8 shared papersPlant Biology

Y. Jami-Alahmadi

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10 papers

Recent·Most cited

ACD15, ACD21, and SLN regulate accumulation and mobility of MBD6 to silence genes and transposable elements.

B. A. Boone, L. Ichino, S. Wang, J. Gardiner, J. Yun, Y. Jami-Alahmadi, J. Sha, C. P. Mendoza, B. J. Steelman, A. v. Aardenne, S. Kira-Lucas, I. Trentchev, J. Wohlschlegel, S. E. Jacobsen

The paper shows ACD15 and ACD21 are essential for MBD5/6 complex accumulation and mobility, which silences genes and transposable elements in Arabidopsis.

Science Advances · Nov 17, 2023Peer-reviewedCell Biology

Toxoplasma gondii encodes an array of TBC-domain containing proteins including an essential regulator that targets Rab2 in the secretory pathway

J. J. Quan, L. A. Nikolov, J. Sha, J. Wohlschlegel, P. J. Bradley

This study identifies TgTBC9 as an essential TBC-domain protein in Toxoplasma gondii that regulates Rab2 and ER-to-Golgi trafficking, offering therapeutic targets for apicomplexan parasites.

bioRxiv · May 28, 2023 · PreprintMicrobiology

Arabidopsis TRB proteins function in H3K4me3 demethylation by recruiting JMJ14

M. Wang, Z. Zhong, J. Gallego-Bartolome, S. Feng, Y.-H. Shih, M. Liu, J. Zhou, J. C. Richey, C. Ng, Y. Jami-Alahmadi, J. Wohlschlegel, K. Wu, S. E. Jacobsen

This study shows TRB proteins recruit JMJ14 to demethylate H3K4me3 and coordinate with PRC2 to repress target genes.

bioRxiv · Jan 10, 2023 · PreprintPlant Biology

The MOM1 complex recruits the RdDM machinery via MORC6 to establish de novo DNA methylation.

Z. Li, M. Wang, Z. Zhong, J. Gallego-Bartolome, S. Feng, Y. Jami-Alahmadi, X. Wang, J. Wohlschlegel, S. Bischof, J. A. Long, S. E. Jacobsen

The paper shows MOM1 recruits RdDM machinery via MORC6 to establish de novo DNA methylation and maintain chromatin state at RdDM sites.

bioRxiv · Jan 10, 2023 · PreprintPlant Biology

A gene silencing screen uncovers diverse tools for targeted gene repression in Arabidopsis

M. Wang, Z. Zhong, J. Gallego-Bartolome, Z. Li, S. Feng, P. H. Kuo, R. L. Kan, J. Richey, Y. Jami-Alahmadi, J. Wohlschlegel, S. E. Jacobsen

The paper identifies multiple proteins that can silence genes in Arabidopsis through various epigenetic mechanisms and develops a machine learning model to predict silencing efficacy.

bioRxiv · Nov 1, 2022Plant Biology

Multi-site phosphorylation of the TOPBP1 ATR Activation Domain propels ATR signaling during the response to DNA breaks

H. Senebandith, K. Ruis, K. Montales, O. Huynh, Y. Jami-Alahmadi, J. Wohlschlegel, W. M. Michael

This study identifies multi-site phosphorylation of the TOPBP1 ATR activation domain as critical for ATR activation during DNA damage response.

bioRxiv · Sep 19, 2022 · PreprintCell Biology

A genetic model for in vivo proximity labeling of the mammalian secretome

R. Yang, A. S. Meyer, I. A. Droujinine, N. D. Udeshi, Y. Hu, J. Guo, J. A. McMahon, D. K. Carey, C. Xu, Q. Fang, J. Sha, S. Qin, D. Rocco, J. Wohlschlegel, A. Y. Ting, , A. P. McMahon

This paper introduces a genetic mouse model for in vivo proximity labeling of the secretome, revealing organ-specific secretory profiles and serum trafficking.

bioRxiv · Apr 13, 2022Cell Biology

The dynamics of HD-ZIP III - ZPR protein interactions play essential roles in embryogenesis, meristem function and organ development

A. Vitlin Gruber, M. Kosty, Y. Jami-Alahmadi, J. Wohlschlegel, J. A. Long

This study investigates the roles of ZPR proteins in plant development by analyzing their interactions with HD-ZIP III transcription factors through genetics, imaging, and biochemistry.

bioRxiv · Nov 24, 2021 · PreprintPlant Biology

Divergent Acyl Carrier Protein Decouples Mitochondrial Fe-S Cluster Biogenesis from Fatty Acid Synthesis in Malaria Parasites

S. Falekun, J. Sepulveda, Y. Jami-Alahmadi, H. Park, J. Wohlschlegel, P. A. Sigala

This paper identifies a divergent acyl carrier protein in Plasmodium that couples mitochondrial Fe-S cluster biogenesis to the electron transport chain, independent of fatty acid synthesis.

bioRxiv · Apr 13, 2021Microbiology

The plant mobile domain proteins MAIN and MAIL1 interact with the phosphatase PP7L to regulate gene expression and silence transposable elements in Arabidopsis thaliana.

M. Nicolau, N. Picault, J. Descombin, Y. Jami-Alahmadi, S. Feng, E. Bucher, S. E. Jacobsen, J.-M. Deragon, J. Wohlschlegel, G. Moissiard

The paper identifies an interaction between PMD proteins MAIN and MAIL1 with the phosphatase PP7L that regulates gene expression and silences transposable elements in Arabidopsis thaliana.

bioRxiv · Jan 17, 2020Plant Biology