Author

K. Smith-Fry

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Organism:mouse· 3 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Organism:human· 2 Approach:statistical model· 2

Frequent Co-Authors

J. Li· 3 shared K. B. Jones· 3 shared L. Li· 3 shared M. Hirst· 2 shared T. O. Nielsen· 2 shared X. Zhang· 2 shared A. Banito· 1 shared A. C. Faber· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersCancer Biology

J. Li

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3 papers

Recent·Most cited

SS18::SSX redistributes BAF chromatin remodelers selectively to activate and repress transcription

J. Li, L. Li, K. Smith-Fry, Z. F. Wilmot, L. Carroll, L. Morrison, X. Ge, M. Nelson, L. A. Hill, X. Zhang, T. O. Nielsen, M. Hirst, T. M. Underhill, B. Cairns, K. B. Jones

This paper shows SS18::SSX fusion protein alters BAF chromatin remodeler distribution, leading to transcriptional activation and repression by changing histone modifications at regulatory regions.

bioRxiv · May 14, 2024 · PreprintCancer Biology

Targeting of SUMOylation leads to cBAF complex stabilization and disruption of the SS18::SSX transcriptome in Synovial Sarcoma

K. V. Floros, C. K. Fairchild, J. Li, K. Zhang, J. L. Roberts, R. Kurupi, B. Hu, V. Kraskauskiene, N. Hosseini, S. Shen, M. M. Inge, K. Smith-Fry, L. Li, A. Sotiriou, K. M. Dalton, , A. C. Faber

This study shows that inhibiting SUMOylation with TAK-981 stabilizes cBAF complexes and disrupts the SS18::SSX-driven transcriptome in synovial sarcoma, leading to tumor inhibition.

bioRxiv · Apr 25, 2024 · PreprintCancer Biology

ASPSCR1-TFE3 reprograms transcription by organizing enhancer loops around hexameric VCP/p97

A. Pozner, S. P. Verma, L. Li, S. Wang, J. J. Barrott, M. L. Nelson, J. S. E. Yu, G. L. Negri, S. Colborne, C. S. Hughes, J.-F. Zhu, S. L. Lambert, L. S. Carroll, K. Smith-Fry, M. G. Stewart, , K. B. Jones

This study identifies VCP/p97 as an obligate co-factor of ASPSCR1-TFE3, showing it organizes enhancer loops to drive oncogenic transcription in ASPS and RCC.

bioRxiv · Sep 29, 2023Cancer Biology