Systematic deconstruction of myeloid cell signaling in tuberculosis granulomas reveals IFN-γ, TGF-β, and time are associated with conserved myeloid diversity
J. M. Peters, H. P. Gideon, T. K. Hughes, C. E. Gunnarson, P. Maiello, D. Mugahid, S. K. Nyquist, J. Bromley, P. C. Blainey, B. F. Junecko, M. L. Nelson, D. A. Lauffenburger, P. L. Lin, J. L. Flynn, A. K. Shalek, , B. D. Bryson
This study uses multi-omics approaches to analyze myeloid cell diversity in TB granulomas and identifies IFN-γ, TGF-β, and time as factors driving macrophage diversity.
bioRxiv · May 24, 2024 · PreprintImmunology