Cell BiologybioRxiv
Mitochondrial One-Carbon Metabolism is Required for TGF-β-Induced Glycine Synthesis and Collagen Protein Production
A. Y. Meliton, R. Cetin-Atalay, Y. Tian…·R. B. Hamanaka
This study shows that mitochondrial one-carbon metabolism is essential for TGF-β-induced glycine synthesis and collagen production in lung fibroblasts, suggesting MTHFD2 inhibitors could treat IPF.
DOI 10.1038/s41467-025-64320-2