Author

A. Muir

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 8 Immunology· 3 Ecology· 2 Microbiology· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 16 Organism:human· 9 Research Focus:cell type annotation· 6 Research Focus:differential expression· 6 Research Focus:cancer & tumor microenvironment· 5 Organism:mouse· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:metabolism & bioenergetics· 4

Frequent Co-Authors

M. G. Vander Heiden· 6 shared C. A. Lewis· 4 shared A. Ali· 3 shared c. Krueger· 3 shared M. Hansen· 3 shared T. Kunchok· 3 shared B. I. Reinfeld· 2 shared B. T. Do· 2 shared

Activity by Year

2017-2023 · peak 8/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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6 shared papersCancer Biology

M. G. Vander Heiden

Mutual co-authors in cluster

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18 papers

Recent·Most cited

Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability

K. L. Abbott, A. Ali, B. I. Reinfeld, A. A. I. Deik, S. Subudhi, M. D. Landis, R. A. Hongo, K. L. Young, T. Kunchok, C. S. Nabel, K. D. Crowder, J. R. Kent, M. L. L. Madariaga, R. K. Jain, K. E. Beckermann, , M. G. Vander Heiden

This study profiles metabolites in renal cell carcinoma tissue and fluid to show that nutrient availability is more influenced by tissue-specific factors than tumor-driven changes.

bioRxiv · Dec 24, 2023Cancer Biology

Single-cell analysis reveals lasting immunological consequences of influenza infection and respiratory immunisation in the pig lung

A. Muir, B. Paudyal, S. Schmidt, E. Sedaghat-Rostani, S. Chakravarti, S. Villanueva Hernandez, K. Moffat, N. Polo, N. Angelopoulos, A. Schmidt, M. Tenbusch, G. Freimanis, W. Gerner, A. C. Richard, E. Tchilian

This study uses single-cell RNA sequencing and flow cytometry to analyze immunological changes in pig lungs after influenza infection or vaccination, revealing lasting effects on immune cell populations and function.

bioRxiv · Dec 19, 2023 · PreprintImmunology

Mitochondrial One-Carbon Metabolism is Required for TGF-β-Induced Glycine Synthesis and Collagen Protein Production

A. Y. Meliton, R. Cetin-Atalay, Y. Tian, J. C. Szafran, K. W. D. Shin, T. Cho, K. A. Sun, P. S. Woods, O. R. Shamaa, B. Chen, A. Muir, G. M. Mutlu, R. B. Hamanaka

This study shows that mitochondrial one-carbon metabolism is essential for TGF-β-induced glycine synthesis and collagen production in lung fibroblasts, suggesting MTHFD2 inhibitors could treat IPF.

bioRxiv · Nov 7, 2023Cell Biology

Human immune phenotyping reveals accelerated aging in type 1 diabetes

M. R. Shapiro, X. Dong, D. Perry, J. M. McNichols, P. Thirawatananond, A. L. Posgai, L. Peters, K. Motwani, R. Musca, A. Muir, P. Concannon, L. Jacobsen, C. E. Mathews, C. H. Wasserfall, M. J. Haller, , T. M. Brusko

The paper uses flow cytometry to show accelerated immune aging and age-adjusted proinflammatory phenotypes in type 1 diabetes.

JCI Insight · Sep 8, 2023Peer-reviewedImmunology

The adaptive immune response to Trichuris in wild versus laboratory mice: An established model system in context

I. Mair, J. Fenn, A. Wolfenden, A. Lowe, A. Bennett, A. Muir, J. Thompson, O. Dieumerci, L. Logunova, S. Shultz, K. J. Else, J. E. Bradley

The paper compares immune responses to Trichuris muris in wild and laboratory mice, finding quantitative differences and age-specific effects in cytokine production and Th1/Th2 balance.

bioRxiv · Aug 28, 2023 · PreprintImmunology

Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression

M. C. Hasselluhn, A. R. Decker-Farrell, L. Vlahos, D. H. Thomas, A. Curiel-Garcia, H. C. Maurer, U. N. Wasko, L. Tomassoni, S. A. Sastra, C. F. Palermo, T. C. Dalton, A. Ma, F. Li, E. J. Tolosa, H. Hibshoosh, , K. P. Olive

The paper identifies a paracrine signaling cascade involving SHH, WNT, and VEGF that suppresses angiogenesis in pancreatic cancer using tumor explant models.

bioRxiv · Mar 2, 2023Cancer Biology

Screening in serum-derived medium reveals differential response to compounds targeting metabolism

K. L. Abbott, A. Ali, D. Casalena, B. T. Do, R. Ferreira, J. H. Cheah, C. K. Soule, A. Deik, T. Kunchok, D. R. Schmidt, S. Renner, S. E. Honeder, M. Wu, S. H. Chan, T. Tseyang, , M. G. Vander Heiden

The paper screens compounds targeting metabolism in serum-derived medium to identify differential responses in cancer cells, aiming to improve drug response prediction.

bioRxiv · Feb 25, 2023Cancer Biology

HYENA detects oncogenes activated by distal enhancers in cancer

A. Yu, A. E. Yesilkanal, A. Thakur, F. Wang, Y. Yang, W. Phillips, X. Wu, A. Muir, X. He, F. Spitz, L. Yang

HYENA identifies oncogenes, including non-coding genes, activated by enhancer hijacking in cancer using whole-genome and transcriptome sequencing data.

bioRxiv · Jan 9, 2023Cancer Biology

Cell envelope remodeling requires high concentrations of biotin during Mycobacterium abscessus model lung infection

M. R. Sullivan, K. McGowen, Q. Liu, C. Akusobi, D. C. Young, J. A. Mayfield, S. Raman, I. D. Wolf, D. B. Moody, C. C. Aldrich, A. Muir, E. J. Rubin

This study identifies biotin-dependent fatty acid remodeling as essential for Mycobacterium abscessus survival in the lung, suggesting biotin synthesis and fatty acid metabolism as therapeutic targets.

bioRxiv · Jul 20, 2022 · PreprintMicrobiology

Pancreatic tumors activate arginine biosynthesis to adapt to myeloid-driven amino acid stress

J. J. A. Saab, L. N. Dzierozynski, P. B. Jonker, Z. Zhu, R. N. Chen, M. Oh, C. Sheehan, K. F. Macleod, C. R. Weber, A. Muir

The paper develops a cell culture medium mimicking the PDAC tumor microenvironment and identifies arginine biosynthesis as a metabolic adaptation to myeloid-driven arginine starvation.

bioRxiv · Jun 21, 2022Cancer Biology

Temporal instability of lake charr phenotypes: synchronicity of growth rates and morphology linked to environmental variables?

L. Chavarie, S. Voelker, M. Hansen, C. Bronte, A. Muir, M. Zimmerman, c. Krueger

The paper examines phenotypic variation in lake charr ecotypes over time, finding a synchronized shift in morphology and growth rates linked to environmental changes like cloud cover.

bioRxiv · Aug 13, 2020Evolutionary Biology

Construction of a complete set of Neisseria meningitidis defined mutants - the NeMeSys 2.0 collection - and its use for the phenotypic profiling of the genome of an important human pathogen

A. Muir, I. Gurung, A. Cehovin, A. Bazin, D. Vallenet, V. Pelicic

The paper constructs a comprehensive mutant collection for Neisseria meningitidis and identifies essential genes and novel gene functions related to key biological processes.

bioRxiv · Aug 12, 2020Microbiology

Cell Programmed Nutrient Partitioning in the Tumor Microenvironment

B. I. Reinfeld, M. Z. Madden, M. M. Wolf, A. Chytil, J. E. Bader, A. R. Patterson, A. S. Cohen, A. Ali, B. T. Do, C. A. Lewis, A. Muir, R. A. Hongo, K. L. Young, R. E. Brown, V. M. Todd, , W. K. Rathmell

The paper measures nutrient uptake in the tumor microenvironment using PET tracers and finds cancer cells prefer glutamine while myeloid cells consume most glucose.

bioRxiv · Aug 10, 2020 · PreprintCancer Biology

Among-individual diet variation within a lake trout ecotype: lack of stability of niche use.

L. B. Chavarie, K. Howland, L. Harris, C. Gallagher, M. Hansen, W. Tonn, A. Muir, C. Krueger

The paper examines diet variation among lake trout within an ecotype, finding that individual trophic specialization occurs despite lack of genetic or morphological differentiation.

bioRxiv · Jul 29, 2020Ecology

Netrin G1 promotes pancreatic tumorigenesis through cancer associated fibroblastdriven nutritional support and immunosuppression

R. Francescone, D. Barbosa Vendramini-Costa, J. Franco-Barraza, J. Wagner, A. Muir, A. N. Lau, L. Gabitova, T. Pazina, S. Gupta, T. Luong, N. Shah, D. Rollins, R. Malik, R. Thapa, D. Restifo, , E. Cukierman

This study identifies Netrin G1 as a promoter of pancreatic ductal adenocarcinoma tumorigenesis by enhancing cancer-associated fibroblast-driven metabolic support and immunosuppression.

bioRxiv · May 30, 2020Cancer Biology

Dietary vs non-dietary fatty acid profiles of lake trout ecotypes from Lake Superior and Great Bear Lake: Are fish really what they eat?

L. Chavarie, J. Hoffmann, A. Muir, C. Krueger, C. Bronte, K. Howland, C. Gallagher, S. Sitar, M. Hansen, M. Vinson, L. Loseto, W. Tonn, H. Swanson

The paper examines non-dietary fatty acid profiles in lake trout ecotypes to assess their ability to distinguish intraspecific diversity across lakes and ecotypes.

bioRxiv · Apr 6, 2020Ecology

Quantification of microenvironmental metabolites in murine cancer models reveals determinants of tumor nutrient availability

M. R. Sullivan, L. V. Danai, C. A. Lewis, S. H. Chan, D. Y. Gui, T. Kunchok, E. A. Dennstedt, M. G. Vander Heiden, A. Muir

The paper quantifies microenvironmental metabolites in murine cancer models and identifies factors affecting tumor nutrient availability.

bioRxiv · Jan 3, 2019Cancer Biology

Environmental cystine drives glutamine anaplerosis and sensitizes cells to glutaminase inhibition

A. Muir, L. V. Danai, D. Y. Gui, C. Y. Waingarten, M. G. Vander Heiden

The paper shows that environmental cystine levels influence glutamine anaplerosis and glutaminase dependence in cancer cells.

bioRxiv · Apr 11, 2017Biochemistry