Y. Tian

An anatomical and day-night atlas links cochlear immunity to adjacent bone marrow

This study links cochlear immunity to adjacent bone marrow through anatomical and day-night profiling in mice, revealing synchronized clocks and immune cell dynamics.

Biocatalytic Asymmetric Radical Dearomatization of Electrophilic Heterocyclic and Non-Heterocyclic Arenes

This paper develops biocatalytic methods for asymmetric radical dearomatization of electrophilic arenes, achieving stereoselective transformations of challenging substrates.

Scalable Generation of Clinical-Grade Universal Human cDC1s Enables Potent Antitumor Immunotherapy

This paper develops a scalable method to generate clinical-grade cDC1s from umbilical cord blood, showing improved antitumor efficacy in mouse models and recapitulating DC differentiation.

Dynamic Regulation of Innate Lymphoid Cell Development During Ontogeny

This study investigates the developmental changes in innate lymphoid cell (ILC) subsets using scRNA-seq and differentiation assays, revealing distinct regulatory programs in fetal and adult stages.

Cynipid wasps systematically reprogram host metabolism and restructure cell walls in developing galls

This study investigates how Cynipid wasps alter plant metabolism and cell wall structure to form galls, revealing coordinated lignin and xylan deposition in gall vasculature.

Multiple Omics Find New Cecal Microbial Features Associated with Feed Efficiency in Ducks

The paper identifies microbial and metabolic differences associated with feed efficiency in ducks using metagenomics, transcriptomics, and metabolomics.

Development of a Two-Leaf Photosynthetic Model Sensitive to Chlorophyll and Its Coupling with a Wheat Growth Model

This study develops a two-leaf photosynthetic model sensitive to chlorophyll and couples it with a wheat growth model to better understand the effects of nitrogen dynamics and diffuse light on photosynthesis.

Structural architecture of amyloid-β oligomers, curvilinear protofibrils and annular assemblies, imaged by cryo-EM and cryo-ET

The paper uses cryo-EM and cryo-ET to characterize the structural architecture of Aβ oligomers, curvilinear protofibrils, and annular assemblies, revealing their structural relationships and functional properties.

ATG6 interacting with NPR1 increases Arabidopsis thaliana resistance to Pst DC3000/avrRps4 by increasing its nuclear accumulation and stability

This study shows ATG6 interacts with NPR1, enhancing its nuclear accumulation and stability, which boosts Arabidopsis resistance to Pst DC3000/avrRps4.

Unraveling the gut microbiota of Tibetan chickens: insights into highland adaptation and ecological advantages

This study compares the gut microbiota of Tibetan chickens from different environments to identify adaptations to high-altitude conditions.

Nature AND Nurture: Enabling formate-dependent growth in Methanosarcina acetivorans

This study enables formate-dependent methanogenesis in Methanosarcina acetivorans through metabolic engineering and adaptive evolution, expanding its substrate utilization capabilities.

Discrimination of Isomeric Glycans via High-sensitive Engineered Nanopore

This paper designs an engineered nanopore to distinguish isomeric glycans with high sensitivity and achieves over 90% separation accuracy without machine learning.

Comparison of chronic aerosol inhalation with combustible cigarette and e-cigarette on the psychiatric behaviors and neuroimmune profile in mice

This study compares the effects of combustible cigarette and e-cigarette aerosol inhalation on psychiatric behaviors and neuroimmune profiles in mice, finding greater anxiety in combustible cigarette exposure.

pan-MHC and cross-Species Prediction of T Cell Receptor-Antigen Binding

This paper develops pMTnet-omni, an AI system predicting TCR-pMHC binding across species and MHC classes, achieving high accuracy and showing clinical utility in predicting immune-related adverse events.

Mitochondrial One-Carbon Metabolism is Required for TGF-β-Induced Glycine Synthesis and Collagen Protein Production

This study shows that mitochondrial one-carbon metabolism is essential for TGF-β-induced glycine synthesis and collagen production in lung fibroblasts, suggesting MTHFD2 inhibitors could treat IPF.

A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity

This study shows that a ketogenic diet reduces autoimmune disease in mice by altering host metabolism and shaping gut microbiota, specifically through β-hydroxybutyrate and Lactobacillus species.

MiceVAPORDot: A novel automated approach for high-throughput behavioral characterization during E-cigarette exposure in mice

MiceVAPORDot automates behavioral analysis during e-cigarette exposure in mice, revealing phenotypes not detectable by traditional methods.

Gut microbial genomes with paired isolates from China signify probiotic and cardiometabolic effects

The paper presents a new microbial reference set with paired isolates from China, showing probiotic and cardiometabolic effects on hosts.

A muscle hypertrophy-derived myokine reprograms the stromal vascular fractions differentiation towards thermogenic adipocytes in subcutaneous adipose tissue

This study identifies Thbs4 as a muscle-derived myokine that promotes the conversion of white to beige adipocytes in subcutaneous adipose tissue, improving metabolic health and protecting against high-fat diet-induced disorders.

Stabilization of RRBP1 mRNA via an m6A-dependent manner in prostate cancer constitutes a therapeutic vulnerability amenable to small-peptide inhibition of METTL3

This study identifies METTL3-mediated stabilization of RRBP1 mRNA via m6A in prostate cancer and develops small-peptide inhibitors to target this pathway.

Wiskott-Aldrich Syndrome Protein Regulates Nucleolar Organization and Function in Innate Immune Response

This study shows that WASP regulates nucleolar structure and function, affecting rRNA transcription and inflammatory cytokine response in macrophages.

Forward genetic screening in engineered colorectal cancer organoids identifies novel regulators of metastasis

The paper uses CRISPR/Cas9 screening in colorectal cancer organoids to identify novel metastasis regulators, finding Ctnna1 and Bcl2l13 as metastasis suppressors.

Interchromosomal Colocalization with Parental Genes Is Linked to the Function and Evolution of Mammalian Retrocopies

This study shows that retrocopies and their parental genes colocalize in 3D genome organization, leading to increased transcription, translation, and evolutionary conservation.

Crystal structures reveal nucleotide-induced conformational changes in G motifs and distal regions in guanylate-binding protein 2

This study reveals how GDP binding induces conformational changes in GBP2's G domain and distal regions, leading to dimer-monomer transitions and functional regulation.

Construction of Model Animals to Explore Intestinal Microbiome for Detection of Breast Cancer

This study investigates the relationship between breast cancer and gut microbiome by analyzing fecal samples from mice with induced breast tumors, finding changes in microbial composition and signaling pathways.

The SARS-CoV-2 Spike protein induces long-term transcriptional perturbations of mitochondrial metabolic genes, causes cardiac fibrosis, and reduces myocardial contractile in obese mice

This study shows that the SARS-CoV-2 Spike protein causes long-term mitochondrial gene suppression, cardiac fibrosis, and reduced myocardial contractility in obese mice.

Mapping and modeling human colorectal carcinoma interactions with the tumor microenvironment

This study maps and models human colorectal carcinoma interactions with the tumor microenvironment using single-cell transcriptomics and tumoroid cultures, showing how tumoroids suppress inflammation and reprogram macrophages.

APC and P53 mutations synergize to create a therapeutic vulnerability to NOTUM inhibition in advanced colorectal cancer

This study identifies NOTUM as a therapeutic target in advanced colorectal cancer, showing that its inhibition effectively arrests tumor growth and metastasis in models with APC and P53 mutations.

Dissecting the genetic basis of the heterosis of Y900, an elite super-hybrid rice

The paper identifies genetic and regulatory mechanisms underlying heterosis in the rice hybrid Y900 by analyzing genome and transcriptome data from its parental lines.

Detection of latent Epstein-Barr virus gene expression in single-cell sequencing of peripheral blood mononuclear cells

The paper detects latent EBV gene expression in single-cell RNA sequencing of peripheral blood mononuclear cells and identifies EBV-associated gene upregulation in infected B-lymphocytes.