Author

K. Y. Hostetler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

J. R. Beadle· 2 shared N. Valiaeva· 2 shared A. E. Clark· 1 shared A. F. Carlin· 1 shared A. F. Garretson· 1 shared C. F. Spiropoulou· 1 shared J. A. Murphy· 1 shared J. Montgomery· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersMicrobiology

J. R. Beadle

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2 papers

Recent·Most cited

Rethinking Remdesivir: Synthesis, Antiviral Activity and Pharmacokinetics of Oral Lipid Prodrugs

R. T. Schooley, A. F. Carlin, J. R. Beadle, N. Valiaeva, X.-Q. Zhang, A. E. Clark, R. E. McMillian, S. L. Leibel, R. N. McVicar, J. Xie, A. F. Garretson, V. I. Smith, J. A. Murphy, K. Y. Hostetler

This paper develops orally bioavailable lipid prodrugs of Remdesivir that show submicromolar anti-SARS-CoV-2 activity and therapeutic plasma levels in Syrian hamsters.

Antimicrobial Agents and Chemotherapy · Sep 17, 2021Peer-reviewedMicrobiology

Broad-spectrum in vitro antiviral activity of ODBG-P-RVn: an orally-available, lipid-modified monophosphate prodrug of remdesivir parent nucleoside (GS-441524)

M. K. Lo, P. Shrivastava-Ranjan, P. Chatterjee, M. Flint, J. R. Beadle, N. Valiaeva, R. Schooley, K. Y. Hostetler, J. Montgomery, C. F. Spiropoulou

This study evaluates the antiviral activity of ODBG-P-RVn, an orally available prodrug of remdesivir, against SARS-CoV-2 and other viruses in human airway cells, showing improved efficacy compared to GS-441524.

bioRxiv · Aug 6, 2021Pharmacology & Toxicology