The Interaction of Viperin with Hepatitis C Virus Non-Structural Protein 5A Inhibits the Catalytic Activity of Viperin
S. Ghosh, A. M. Patel, T. J. Grunkemeyer, A. B. Dumbrepatil, K. Zagalia, R. T. Kennedy, E. N. G. Marsh
This study shows viperin interacts with NS5A and VAP-33, reducing NS5A levels and viperin activity, suggesting NS5A evolved to inhibit ddhCTP synthesis.
bioRxiv · Oct 30, 2019 · PreprintBiochemistry