K.-H. Ho

Glucose-stimulated KIF5B-driven microtubule sliding organizes microtubule networks in pancreatic beta cells

This study shows that glucose stimulates KIF5B-mediated microtubule sliding in pancreatic beta cells, organizing microtubule networks to support insulin secretion and prevent hypoglycemia.

The microtubule minus end-binding protein CAMSAP2 does not regulate microtubule dynamics in primary pancreatic β-cells but facilitates insulin secretion

This study shows that CAMSAP2 in primary pancreatic β-cells localizes to the Golgi and supports insulin secretion by facilitating Golgi-ER trafficking, despite not regulating microtubule dynamics.

Microtubules and Gαo-signaling independently regulate the preferential secretion of newly synthesized insulin granules in pancreatic islet β cells

The paper investigates how microtubules and Gαo-signaling regulate the preferential secretion of newly synthesized insulin granules in β cells, showing that their absence leads to increased secretion of older granules.

Microtubules Regulate Spatial Localization and Availability of Insulin Granules in Pancreatic Beta Cells.

This study shows microtubules regulate insulin granule localization and PM interactions in beta cells, affecting GSIS and suggesting MT targeting as a diabetes therapy.