Author

K.-K. Yan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

J. Yu· 3 shared J. Silva· 2 shared A. Bahrami· 1 shared A. Shelat· 1 shared A. Sykes· 1 shared A. Zebisch· 1 shared B. Ju· 1 shared B. Shaner· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCancer Biology

J. Yu

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The miR-424/503 cluster modulates Wnt/β-catenin signaling in the mammary epithelium by regulating the expression of the LRP6 co-receptor

E. A. Nekritz, R. Rodriguez-Barrueco, K.-K. Yan, M. L. Davis, R. L. Werner, L. Devis-Jauregui, P. Mukhopadhyay, J. Yu, D. Llobet-Navas, J. Silva

The paper identifies the miR-424/503 cluster as a regulator of Wnt/β-catenin signaling in mammary epithelium by targeting LRP6, and links its loss to breast cancers with high Wnt/β-catenin activity.

bioRxiv · May 6, 2021 · PreprintCancer Biology

Interrogation of SLFN11 in pediatric sarcomas uncovers an unexpected biological role and a novel therapeutic approach to overcoming resistance to replicative stress

J. Gartrell, M. Mellado-Lagarde, N. Martinez, M. Clay, A. Bahrami, N. Sahr, A. Sykes, K. Blankenship, L. Hoffmann, J. Xie, H. P. Cho, N. Twarog, M. Connelly, K.-K. Yan, J. Yu, , A. Shelat

This study investigates SLFN11's role in pediatric sarcomas, finding it promotes tumor growth and resistance to DNA-damaging agents, which can be overcome by BCL-XL inhibition.

bioRxiv · Nov 5, 2020 · PreprintCancer Biology

miR-424(322) is a molecular switch controlling pro-inflammatory vs anti-inflammatory skin DC subset differentiation by modulating TGF-β signaling

V. Zyulina, K.-K. Yan, B. Ju, C. Passegger, C. Tam-Amersdorfer, Q. Pan, T. Sconocchia, C. Pollack, B. Shaner, A. Zebisch, J. Easton, J. Yu, J. Silva, H. Strobl

This study identifies miR-424(322) as a molecular switch that controls the differentiation of pro-inflammatory monocyte-derived DCs (moDCs) versus anti-inflammatory Langerhans cells (LCs) by modulating TGF-β signaling.

bioRxiv · Sep 7, 2020 · PreprintImmunology