The miR-424/503 cluster modulates Wnt/β-catenin signaling in the mammary epithelium by regulating the expression of the LRP6 co-receptor
E. A. Nekritz, R. Rodriguez-Barrueco, K.-K. Yan…·J. Silva
The paper identifies the miR-424/503 cluster as a regulator of Wnt/β-catenin signaling in mammary epithelium by targeting LRP6, and links its loss to breast cancers with high Wnt/β-catenin activity.