Author
Cold Spring Harbor LaboratoryORCID 0000-0001-7248-7506Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Klaske M. Schukken, Saron M. Akalu, Charles Zou…·Jason M. Sheltzer
Patrick J. Cunniff, Connor Fitzpatrick, Jack Bauer…·Christopher R. Vakoc
The paper identifies POU2F1 as a key regulator of DLL3 and neuroendocrine identity in SCLC through CRISPR screens and epigenomic analysis.
Kaitlin Long, Debanjan Bhattacharjee, Samuel H. Newman-Stonebraker…·Jason M. Sheltzer
This study reveals that PAC-1, a clinical-stage oncology compound, targets drug-resistant cancers by disrupting iron homeostasis and exploiting MDR1 expression to induce iron depletion.
Olaf Klingbeil, Damianos S. Skopelitis, Claudia Tonelli…·Christopher R. Vakoc
This study identifies MARK2/3 as essential kinases for YAP/TAZ function in cancer and shows their inhibition can restore Hippo pathway tumor suppression.
Tongchen He, Lanbo Xiao, Yuanyuan Qiao…·Arul M. Chinnaiyan
This study identifies a therapeutic vulnerability in POU2F-POU2AF-driven cancers by showing that targeting the mSWI/SNF complex with a PROTAC degrader reduces tumor growth in preclinical models.
Hsiang-Chen Chou, Kuhulika Bhalla, Osama El Demerdesh…·Bruce Stillman
This study shows ORC subunits and CDC6 are essential for pre-RC assembly, mitosis, and nuclear structure in human cells.