Tuning Insulin Receptor Signaling Using De Novo Designed Agonists
Xinru Wang, Sarah Caixeta Cardoso, Kai Cai, Preetham Venkatesh, Albert Hung, Michelle Ng, Catherine Hall, Brian Coventry, David S. Lee, Rishabh Chowhan, Stacey Gerben, Jie Li, Weidong An, Mara Hon, Michael C. Gao, , David A. Baker
This paper designs synthetic insulin receptor agonists that modulate receptor conformation and signaling, showing improved potency and activity in disease mutants.
Molecular Cell · Oct 15, 2025Peer-reviewedBioengineering