Author

Weidong An

The University of Texas Southwestern Medical CenterORCID 0000-0002-1897-0318Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1

Frequent Co-Authors

Albert HungiD· 1 shared Brian CoventryiD· 1 shared Catherine HalliD· 1 shared David A. BakeriD· 1 shared David S. LeeiD· 1 shared Domenico AcciliiD· 1 shared Eunhee ChoiiD· 1 shared Gabriel Grenot· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperBioengineering

Albert HungORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

ENPP1 buffers extracellular cGAMP in brown adipose tissue to limit insulin resistance

Songnan Wang, Yingjie Guo, Weidong An, J. Michelle Lee, Yu Li, Valentino Sudaryo, Jacqueline A. Carozza, Gabriel Grenot, Gemini M. Skariah, Saranya Chidambaranathan Reghupaty, Sonny Young, Xiaochen Bai, Katrin J. Svensson, Lingyin Li

This study shows that the ENPP1 K173Q variant reduces cGAMP hydrolysis, leading to increased extracellular cGAMP and insulin resistance in brown adipose tissue.

Cell Reports · Sep 15, 2026Peer-reviewedImmunology

Tuning Insulin Receptor Signaling Using De Novo Designed Agonists

Xinru Wang, Sarah Caixeta Cardoso, Kai Cai, Preetham Venkatesh, Albert Hung, Michelle Ng, Catherine Hall, Brian Coventry, David S. Lee, Rishabh Chowhan, Stacey Gerben, Jie Li, Weidong An, Mara Hon, Michael C. Gao, , David A. Baker

This paper designs synthetic insulin receptor agonists that modulate receptor conformation and signaling, showing improved potency and activity in disease mutants.

Molecular Cell · Oct 15, 2025Peer-reviewedBioengineering