Author

Sarah Caixeta Cardoso

Columbia University Irving Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Albert HungiD· 2 shared David A. BakeriD· 2 shared Domenico AcciliiD· 2 shared Eunhee ChoiiD· 2 shared Michelle Ng· 2 shared Xinru WangiD· 2 shared Brian CoventryiD· 1 shared Catherine HalliD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersPharmacology & Toxicology

Albert HungORCID

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2 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintMay 7, 2026

Reprogramming insulin receptor activation with a de novo agonist to overcome severe insulin resistance

Albert Hung, Xinru Wang, Michael Gao…·Eunhee Choi

This study develops a de novo insulin receptor agonist, RF-409, which effectively treats severe insulin resistance in a mouse model by activating a mutant receptor and improving glucose homeostasis.

DOI 10.64898/2026.05.04.722722

mouseproteomics

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BioengineeringMolecular CellPeer-reviewedOct 15, 2025

Tuning Insulin Receptor Signaling Using De Novo Designed Agonists

Xinru Wang, Sarah Caixeta Cardoso, Kai Cai…·David A. Baker

This paper designs synthetic insulin receptor agonists that modulate receptor conformation and signaling, showing improved potency and activity in disease mutants.

25 citationstop 2%

humanproteomics

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